ePoster

How does the dorsal striatum contribute to active choice rejection?

Jaclyn Essig,Albert Jiaxu Qü,Zichen Zhou,Lung-Hao Tai,Linda Wilbrecht
COSYNE 2022(2022)
Lisbon, Portugal
Presented: Mar 19, 2022

Conference

COSYNE 2022

Lisbon, Portugal

Resources

Authors & Affiliations

Jaclyn Essig,Albert Jiaxu Qü,Zichen Zhou,Lung-Hao Tai,Linda Wilbrecht

Abstract

Choice rejection is an important part of decision making with high clinical relevance for addiction. Our goal is to understand how neural circuits are engaged during active rejection. This question is largely understudied due to a focus on choice omission, freezing, or stopping in animal studies of behavioral control. Similarly, two-alternative forced choice studies of decision making also fail to isolate active rejection from acceptance since these two aspects of decision making occur in parallel in these tasks. To better isolate active rejection, we adapted a serial decision-making task, Restaurant Row, in which mice decide to either accept or reject reward offers as they traverse four interconnected T-mazes. Mice report accept choices by turning right for an opportunity to receive a food pellet or turn left to actively reject an offer and continue to the next T-junction. Fiber photometry recordings were used to compare dSPN or iSPN activity preceding reject choices at each T-junction in Restaurant Row. We also recorded from these same mice in a two-arm bandit (2ABT) task.

Unique ID: cosyne-22/does-dorsal-striatum-contribute-active-a1a0441f