Psychedelic compounds act upon the serotonergic pathway to generate altered states of consciousness and disrupt normal sensory processing, creating profound perceptual disturbances including visual hallucinations. While psychedelics have recently garnered much attention for their cognitive and therapeutic effects, how psychedelics disrupt sensory processing to evoke hallucinations is not as well characterized. Furthermore, while initial studies have investigated how psychedelics alter visual responses during head-fixation, nothing is known about how they might alter visual processing during active sensation. To address this, we recorded single unit neural activity from the primary visual cortex (V1) of freely-moving mice before and after administration of the psychedelic serotonin 2A receptor agonist, DOI (2,5-dimethoxy-4-iodoamphetamine). During active sensation, freely-moving mice coordinate head and eye movements to adjust their gaze. Previous findings showed that these saccadic movements initiate a ripple of visual activity throughout V1 that carries coarse-to-fine patterned information about the visual scene, as neurons responding immediately after the gaze shift encode coarse, low-spatial frequency (SF) visual information while neurons responding more slowly encode higher SF details about the visual scene. Interestingly, we find that DOI disrupts this temporal pattern of visual input by specifically reducing the response latency of neurons that typically respond slowly after gaze shifts and encode high SFs, while leaving the earliest responding cells, that encode low SFs, largely unaffected. Additionally, we find that DOI has a weak effect on the SF preference of gaze shift responsive neurons, but does strongly alter the temporal frequency (TF) preferences of a subpopulation of gaze shift responsive neurons, shifting responses towards dynamic stimuli. Collectively, these findings illustrate that DOI disrupts the precise timing and coarse-to-fine pattern of visual input that normally occurs after gaze shifts during active sensation.