Common Ground: Both studies focus on neurodegenerative diseases like Parkinson's disease and Dementia with Lewy Bodies and investigate the interactions and accumulations of pathological proteins such as α-synuclein and tau.
Key Differences: The current study primarily examines synaptic co-aggregation of α-synuclein and tau in synapses using array tomography and FRET, whereas the recommended study investigates mitophagy alterations and the accumulation of pS65-Ub in brain regions with LB, NFT, and SP pathology.
Methodologies: The current study uses techniques like array tomography and Förster resonance energy transfer (FRET) on enriched synaptic fractions. The recommended study employs quantitative analysis of pS65-Ub deposits in brain tissues with high-resolution microscopic techniques.
Complementary Aspects: The current study's insights into synaptic dysfunction can be enhanced by the recommended study's findings on mitophagy impairment and the complex interactions between various proteinopathies.
Potential Impact: Combining findings could elucidate molecular mechanisms underlying the synaptic and mitochondrial dysfunction in PD and DLB.

Scheduled maintenance in progress.