Rodents rely heavily on somatosensation to explore their environment. The primary somatosensory cortex (S1) contributes to the encoding and perception of tactile stimuli. Although S1 neurons also receive non-tactile inputs, it is unclear whether S1 similarly encodes non-tactile sensory-based behaviour. Whole-cell patch clamp recordings were used to investigate the voltage response of layer 2/3 (L2/3) pyramidal neurons in S1 during performance in either a tactile-based or auditory-based association task in mice. A robust and sustained voltage response was evoked in L2/3 pyramidal neurons during correct responses in both tasks, indicating that the response was not dependent on the delivery of the tactile stimuli. Furthermore, L2/3 pyramidal neurons were active during spontaneous motor bouts, with voltage responses preceding the motor output. Notably, optogenetic suppression of the primary motor cortex did not affect this motor-correlated activity in the L2/3 neurons of S1. In conclusion, L2/3 pyramidal neurons in S1 are active during motor output, and the activation primarily originates from brain areas other than the motor cortex.