Oxytocin (OXT), a 9-amino acid neuropeptide, plays a critical role in mammal’s social interaction and cognition. Previously, human and animal studies have revealed that intranasal OXT administration may enhance social preferences. However, it is unclear whether age may affect such social preferences by using airborne OXT. Here, we established an OXT preference test in a 40*41 cm rectangle arena (chamber), wherein two plastic tubes harboring OXT-impregnated cotton-tip were in two arena side-sharing corners, and two plastic tubes harboring vehicle-impregnated cotton-tip were in the other. OXT zone was defined by the half arena with two OXT corners, while vehicle zone was the remaining half arena with two vehicle corners. Our results showed that young male mice had significantly higher OXT zone preference, while old male mice did not show any preference. We further investigated whether young male mice may prefer stranger mice with OXT-impregnated cotton-tip. Surprisingly, we noticed young male mice’s OXT zone preference was no longer obvious when OXT cotton-tip was housed with same-sex mouse stranger. These results prompted us to provisionally conclude that young, but not old, male mice showed eminent OXT preference and or vehicle (2% ethanol-containing saline) aversion. Such airborne bias seems to be parceled out by the introduction of same-sex conspecifics.