(Jammal Salameh et al., Science_2024)​​Heartbeat transmission through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we show for the first time that arterial pressure pulsations can directly modulate neuronal activity within the central nervous system via baroreceptive transduction. We recorded local-field-potentials (LFP) within the rat olfactory bulb (OB) using a semi-intact, perfused nose-brain preparation, while monitoring the pressure pulsations induced by the peristaltic perfusion pump that in our setup operated within the physiological range of heartbeat-induced pulsations. We found that slow LFP oscillations matched the pump-induced pulsations (n=13), originated from the vicinity of the mitral cell layer and were sensitive to hypoxia (n=13), yet insensitive to blockade of neuronal spiking (n=9). Cationic fast mechanoreceptors, most likely Piezo2 channels that were recently found in mitral cells, play a crucial role in transducing this baroreceptive response: D-GsMTx4, a TRPC/Piezo channel-blocker, abolished the LFP oscillations, but preserved the spike rate and the basal LFP activity (n=13). The waveform of the slow LFP oscillations derived from the observed spectral harmonics (n=53) was best explained by Piezo2 gating properties. LFP oscillations also entrained spontaneous mitral cell spikes. In-vivo parallel multi-electrode and heartbeat recordings (n=19 animals) confirmed that a subset of OB neurons synchronized their spiking to heartbeat within 20 ms, independently of the presence of nasal-respiration (n=6). Similar heartbeat entrainment was also observed in the hippocampus and prefrontal cortex. We propose that a network of interoceptive ‘heartbeat sentinel neurons’ can modulate cognition and perception, e.g. within the context of arousal.