Neuroinflammation is a fundamental element of many neurodegenerative disorders. Activation of astrocytes and microglia cells leads to a release of cytokines and reactive oxygen species followed by leakage of the blood-brain barrier and neurotoxicity. Transient neuroinflammation is understood to be largely protective, chronic neuroinflammation, however, contributes to the pathology of Alzheimer’s disease, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia cells and especially in astrocytes, since many studies on neuroinflammation concentrate on microglia cells, leaving the role of astrocytes aside. However, how reactive astrocytes interact and integrate into the community of central nervous system cells is not completely understood. Moreover, there is a lack of reliable human in-vitro models to facilitate research focussing on microglia cells and astrocytes combined. Here we show that microglia, activated by TNFα, release a mix of cytokines which in turn activate astrocytes, whereas the activated astrocytes produce astrogliosis markers and also TNFα leading to a circuit of proinflammatory activation. Moreover, we present how the natural compound resveratrol can stop the circuit of proinflammatory activation and facilitate a return to resting conditions. Taken together, these results will contribute to distinguishing between neuroinflammation's causes and effects, a better understanding of underlying mechanisms, and potential treatment options.