Common Ground: Both studies investigate neuropsychiatric disorder pathways and their influence on behavioral phenotypes in mice, with a focus on specific neuronal subgroups.
Key Differences: The current study targets JNK pathway in the hippocampus and other brain regions using AAV vectors, while the recommended study examines TPH2 knockout effects on serotonin levels and PV+ interneuron distribution using optogenetic techniques.
Methodologies: Current study employs systemic AAV vectors, behavioral tests, and mRuby2-tagged JNK inhibitors. The recommended study uses immunofluorescence, Western blot, gene expression analysis, and optogenetic manipulation of PV+ cells.
Complementary Aspects: The current study explores JNK pathway across brain regions while the recommended study offers insights into serotoninergic signaling and impulsivity/aggression via PV+ interneurons, providing a comprehensive look at molecular and cellular underpinnings of behavior.
Potential Impact: Combining findings could enhance understanding of the integrative role of specific pathways and cells in neuropsychiatric disorders, guiding targeted therapeutic strategies.

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