The wide-spread connectivity of the claustrum with the cortex has suggested that it is involved in higher-cognitive functions. However, in mouse recent findings suggest a topographical organization with the cortex and a sensory regionalization of the claustrum. Our earlier work reports important differences in the organizational principals of mouse and primate cortical connectivity. Hence, we have undertaken extensive examination of the projections between claustrum and cortex in macaque using retrograde tracing. Surprisingly, we find that these connections do not obey the exponential distance rule, which is ubiquitous in the cortical network, allowing claustrum to be strongly connected to all neocortical areas. Graph theoretic analysis of these findings show that the claustrum has very high centrality values and that it constitutes the unique hub of the cortex. These results suggest that the spatial embedding of the primate claustrum allows it to play a privileged role in facilitating the orchestration of rapid changes of brain state which we are currently exploring in non-human primate using multisite single unit recording simultaneously across the cortex and in the claustrum.Contact: julien.vezoli@inserm.fr; henry.kennedy@inserm.fr.Funding: BICAN, HMBA, NIH UM1MH130981; ANR-22-CE92-0010-01