Memory consolidation involves the spontaneous activity of multiple brain areas potentially supporting the reprocessing of novel and more remote memories. Traditionally, study of these phenomena has focused on a handful of brain areas, such as hippocampus and the prefrontal cortex. Here, we are currently investigating how wider cortical networks support memory reprocessing. We are doing so by combining optical (wide-field) voltage imaging with laminarly-resolved hippocampal electrophysiology in mice, to get a large-scale view of the brain activity. Animals perform two virtual reality memory task (hippocampus-dependent vs independent). To obtain food reward, mice need to associate or an object or a “place” in the virtual map (recognizing a constellation of multiple cues) to the reward in a virtual 1.5m linear track.This enables us to study the evolution of cortico-hippocampal network while acquiring an hippocampal dependent vs independent memory. We have shown that mice can acquire both tasks and we are now analyzing cortical data, with particular attention to the interaction between the hippocampus and cortical networks centered on the retrosplenial cortex, which we have previously shown to be especially salient during sleep.