During sleep, memories formed in the hippocampus when awake are progressively transferred to the neocortex, where they are reorganised and stabilised to become long-term memories. This consolidation process is believed to occur concurrently with neuronal oscillations such as sleep spindles. Spindles are waxing-and-waning oscillations in the 10-16 Hz frequency range recorded from the brain's surface, originating in the thalamus and transmitted to the neocortex via thalamo-cortical projections. Several types of spindles have been identified, but how they are linked to specific consolidation processes remains unclear.We investigate whether spindles with distinct characteristics are involved in different types of memory. We used a combination of local field potential recordings in 15 cortical areas, optogenetics, and memory testing in mice. Firstly, we conducted two separate learning experiments and observed the impact of learning on spindles in two cortical areas: primary somatosensory cortex (S1) and prefrontal cortex (PFC), as well as its coupling with other brain oscillations. Our findings revealed that sensory exploration increased spindle activity in S1 but not in PFC, while spatial navigation tasks altered the coupling between sharp-wave ripples and spindles specifically in PFC.Secondly, we artificially induced spindles using optogenetic stimulation in different thalamic nuclei during sleep and examined their characteristics. We observed that the prevalence of sigma power in S1 and PFC reflected the topography of thalamic projections originating from the stimulated nuclei.In conclusion, our results suggest that distinct learning experiences are associated with alterations in spindle characteristics, potentially influenced by the specific thalamic nuclei generating them.