Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most common complications associated with prematurity. It may lead to life-lasting cognitive, sensory, motor and behavioral impairments and it has no successful treatment. Nevertheless, it has been suggested that early behavioral intervention programs may have beneficial effects in premature infants. Accordingly, we have analyzed the effects on neuronal damage and behavioral impairment of early exposure to an enriched environment (EE) of a murine model of GM-IVH. GM-IVH was induced by intraventricular collagenase administration to CD1 P7 mice. At P14, animals were exposed to an EE, consisting on 4 different settings that changed weekly until animals were sacrificed at P70. At P56, animals were assessed in the Morris water maze and new object discrimination tests. Postmortem studies included brain atrophy evaluation by cresyl violet, and neuronal density and complexity by NeuN-DAPI and Golgi Cox staining. Myelin basic protein levels were determined by ELISA. Neurofilament light was also analyzed in cerebrospinal fluid and plasma. EE exposure limited brain atrophy by reducing ventricle enlargement, maintained the neuronal density and increased the neuronal complexity after GM-IVH. Lower neurofilament light levels in plasma and cerebrospinal fluid, and increased myelin basic protein levels in the cortex were detected after EE exposure. Learning and memory compromise were also improved by EE exposure. Our data suggest that an early EE exposure results in a reduction of neuronal pathology after GM-IVH that ultimately contributes to improve cognitive impairment.I+D+i Programa operativo del Fondo Europeo de Desarrollo Regional FEDER. Andalucía 2014-2020 (FEDER-UCA18-107189).