Animal ability to orient and navigate requires selecting appropriate motor responses based on the perception and integration of the environmental information. This is the case of the optokinetic response (OKR) in D. melanogaster, where optic flow visual stimulation modulates walking or flying patterns. Despite a large body of literature on OKR, there is still limited understanding about the impact on OKR of concomitant, potentially conflictual, inputs originating from other sensory channels, as happens in the environment (multimodal integration). We combined optic flow stimulation with the presentation of olfactory cues: we chose two active natural repellents and two synthetic “masking” compounds, and delivered them within a continuous air flow directed in the opposite direction with respect to the movement of drifting gratings. We studied the tethered fly’s response while flying or walking, by tracking the head movement and body position, respectively. Flight data show that the olfactory input does not alter the dynamics of the saccadic-like head movement associated with the visual stimulation, however, their number and the time interval between each movement are significantly altered in presence of repellent olfactory cues, but not for masking compounds. Walking fly data show a similar pattern for grounded locomotion: fewer rotations are triggered by the visual stimulation when an opposing odorant gradient is present. Together, these results provide evidence of the multimodal integration during navigation confirming the ecological impact that different compounds could have on insects and highlight the possibility to use the OKR to unravel the real nature of compounds