The aim of this present study is to evaluate the effectiveness of a prehabilitation programme based on pain neuroscience education and administered through educational videos versus another programme based on written exercise recommendations, in patients scheduled for lumbar radiculopathy surgery. This is a randomised pilot study in which ten patients participated, recruited at different Spanish hospitals. The experimental group followed a 4-week prehabilitation programme combining therapeutic exercise, back care education, and pain neuroscience education delivered through videos designed for consumption at home. The control group was provided with written instructions to perform therapeutic exercises during the same prehabilitation time period. Clinical and pshycological outcomes were measured at baseline and at the end of the 4-week prehabilitation programme. Patients in the experimental group reduced the score in all variables (PRE-POST Numeric Pain Rating Scale (NPRS): 1.16; Mc Gill Pain Questionnaire- Short Form: 0.83; Oswestry Disability Index (ODI): 4.66; Depression subscale from Hospital Anxiety and Depression Scale (HADS):0.5; Pain Catastrophising Scale: 11; Tampa Scale for Kinesiophobia (TSK): 2.83) except for Anxiety subscale from HADS. The control group only reduced the score in NPRS (PRE-POST: 0.25), ODI (PRE-POST: 3.5) and TSK (PRE-POST: 1) and, additionaly, these improvements were lower than those achieved by the experimental group. Concluding, a prehabilitation programme based on pain neuroscience education administered through educational videos was superior than written exercise recommendations for improving pain, disability, depression, catastrophizing and kinesiophobia in patients scheduled for lumbar radiculopathy surgery. Further studies with a larger sample size are required to confirm these findings.