Acupuncture is a component of the complex therapeutic and healthcare system of China that has been used for more than 2500 years. Oriental medicine describes how acupoints are associated with internal organs and acupuncture treatment on back-shu points (BSPs) has received attention owing to its ability to control the function of visceral organs. Previous studies suggested that an acupoint is one form of neurogenic inflammation on the skin. In this study, we compared of the anatomic location between neurogenic inflammatory areas in the skin (neurogenic spots) and traditional acupuncture points (BSPs) and investigated whether effectiveness of Neurogenic inflammation spots in the rat model of bile duct ligation (BDL) induced liver injury. Electroacupuncture (EA) at Neurogenic points reduced serum hepatocellular enzyme activities and histological patterns of acute liver injury in BDL rats. In addition, EA inhibited liver inflammation, evidenced by suppressed of inflammatory factors NF-κB, TNF-α and IL-6 expression level. EA also increased prominent anti-inflammatory cytokines TGF-β and IL-10. The results suggest that the BSPs have therapeutic effects on hepatic injury in bile-duct ligated rats. The results suggest that the expression of neurogenic inflammation spots similarly located to BSPs, and electrical stimulation of neurogenic inflammation spots(BSPs) showed therapeutic effects on hepatic injury in bile-duct ligated rats. Acknowledgement: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2018R1A5A2025272, 2020R1A2C1103154), and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI).