Imaging and sensing system based on CMOS imaging device for simultaneous multi-area monitoring

As the field of neuroscience has undergone significant advancements in understanding individual brain regions, research aimed at elucidating neural networks within multiple brain areas is increased. Techniques like fluorescence imaging, including GCaMP, stand out as formidable methodologies within brain function research. However, conventional imaging applications face challenges in simultaneously capturing data from multiple regions, particularly including deep brain area. Therefore, we have developed a system for multiple measurements based on a CMOS imaging device that can be directly implanted into the mouse brain.　Our developed implantable imaging device is compact and lightweight, making it possible to implant the devices in multiple regions of the mouse brain, or to perform simultaneous measurements in combination with other measurement methods such as microdialysis. We aim to achieve multi area simultaneous monitoring with combination of fluorescence imaging and microdialysis or electrophysiology to measure cranial nerve activity [1],[2]. By focusing on establishing novel systems, we aimed to enable new measurements of rodent brains in a freely moving state.Presently, we have been developing a novel measurement system that combines optogenetics technique and fluorescence imaging. Our ongoing efforts are focused on establishing new system as one of the primary objectives of our research. [1] Y. Sunaga et al,” IEEE Access, vol. 9, pp. 55871–55878, 2021.[2] L. Akbar et al.,” Int. J. Mol. Sci., vol. 24, no. 7, 2023.