Parkinson's Disease (PD) presents with debilitating motor and non-motor symptoms affecting patient quality of life (QoL). Deep Brain Stimulation (DBS) holds promise for mitigating motor symptoms but requires further investigation regarding its impact on QoL. The study explored DBS's effects on PD patients' QoL, employing clinical assessments, patient-reported outcomes, and longitudinal follow-up. A prospective cohort study was conducted involving 150 PD patients who underwent DBS surgery. Baseline assessments of motor and non-motor symptoms, alongside QoL, were recorded using standardized scales. Over two years post-DBS surgery, patients received regular follow-ups with repeated assessments, employing statistical analyses, including mixed-effects modelling. Results indicated significant QoL enhancements post-DBS. Mobility scores increased by an average of 30% (p < 0.001), activities of daily living improved by 25% (p < 0.001), emotional well-being increased by 18% (p < 0.01), and social functioning improved by 20% (p < 0.01). These improvements correlated with reductions in motor symptom severity, reflecting a 40% decrease in UPDRS scores (p < 0.001). Non-motor symptoms like depression and anxiety displayed notable amelioration, with a 35% (p < 0.01) and 30% (p < 0.05) reduction, respectively. Longitudinal analysis affirmed sustained QoL enhancement throughout the two-year follow-up. DBS effectively enhances QoL in PD by ameliorating motor and non-motor symptoms. These findings underscore DBS as a valuable therapeutic option for enhancing the overall well-being of Parkinson's Disease patients. Future research should investigate optimal patient selection criteria and long-term outcomes associated with DBS therapy in PD management.