The post status epilepticus (SE) model is one of the most helpful animal models for epilepsy research. In many cases it closely mimics the clinical signs of temporal lobe epilepsy in humans. Although behavioral, electrophysiological and molecular alterations following SE have been extensively studied, corresponding structural changes remain less well explored. However, to optimize the treatment of epilepsy and complications of SE, it is essential to know how effectively they prevent seizure-induced neuronal damage. In the present study, we elucidate ultrastructural changes and quantitative alterations in synaptic parameters in the hippocampal CA1 and CA3 areas of adult male Wistar rats, provoked by kainic acid (KA) induced SE. This drug was injected intraperitoneal, until convulsive seizures were developed. Ultrastructural analysis was performed on 1, 7 and 21 days after SE. During all this period the behavior of animals was monitored. Structural alterations were more numerous in the CA1 area. In general, ultrastructural modifications observed are found to be dependent on the frequency of seizure activities. More extensive alterations were produced by KA after 7 and 21 days SE which induced apoptosis, cell shrinkage, activation of glia, changes in some presynaptic terminals and enlarged astrocyte ensheathment around synaptic components. Morphometric analysis of several parameters of axo-dendritic synapses revealed significant changes in the number of presynaptic terminals, presynaptic mitochondria and length of active zone. Such reflection of epilepsy pathophysiology indicates a relatively long-lasting character of SE-induced ultrastructural alterations.This research was supported by Shota Rustaveli National Science Foundation of Georgia, grant #PHDF-21-1592.