Recent data in macaques showed that the laminar distribution pattern of corticostriatal neurons in the ipsilateral hemisphere largely varied across different areas, independently from density and projecting area, but likely according to the target striatal zone (Borra et al., JNeurosci 2021, 41:1455–69). Furthermore, other data showed that in macaque there are robust crossed corticostriatal projections to the caudate and the putamen (up to 30% of total labeled cells) and that the origin of the direct and the crossed corticostriatal projections is not symmetrical (Borra et al. JNeurosci 2022, 42:7060–76). In the present study, we compared the distribution pattern and size of crossed vs ipsilateral corticostriatal neurons in four macaques in which neural tracers were injected in motor putamen, precommissural putamen, and caudate head. The results showed that, as in the ipsilateral hemisphere, the pattern was multilaminar involving at a variable extent layers III, V, and VI. The laminar distribution pattern in the most labeled areas (motor areas after the injections in motor and precommissural putamen and prefrontal and cingulate areas after the injections in the caudate head) was similar to that observed in the corresponding ipsilateral areas. Preliminary analysis showed that the overall population of the corticostriatal neurons in the contralateral premotor areas hosts a higher percentage of smaller neurons than in the ipsilateral ones. These observations add complexity to the architecture of the striatal input and suggest more complex modes of information processing in the basal ganglia for different motor and nonmotor functions.