Delayed Cerebral Ischemia (DCI), is a complication of sub-Arachnoïdal Hemorrhage (sAH) associated with a high mortality and morbidity, which is responsible for heavy impairments on survivors. DCI is a slow developing pathology and its diagnosis requires concomitant monitoring of functional or motor deficits and brain perfusion or lesions. In our study we aim, after the development and validation of a preclinical DCI model, to investigate the utility of functional ultrasound (fUS) imaging for longitudinal monitoring of DCI. First we have adapted and refined a rodent model for the minimally-invasive induction of sAH, by using percutaneous autologous blood injection in the cisterna magna. Motor impairment was assessed through a specialized Neuroscore and a gait analysis system (CatWalk XT). In parallel, we used fUS imaging for longitudinal and highly-resolved imaging of brain perfusion and of functional connectivity through the neurovascular coupling, both in anaesthetized and in awake and behaving C57/BL6J mice. These measurements were repeated daily over the course of ten days following sAH induction, before brains were extracted and stained for ischemia using Triphenyl Tetrazolium Chloride (TTC). Our results show significant motor impairments in the sAH cohort as compared to saline injected controls. The analysis of fUS and histological results is currently ongoing and we will present our preliminary results on the poster. The successful completion of this project may help, in the future, the development of a novel clinical monitoring approach for a better diagnosis and treatment of DCI.