Subjective cognitive decline (SCD) manifests as a self-perceived deterioration in memory and thinking abilities, undetectable through objective tests, but which is considered as an early at-risk phase for developing mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Understanding the brain structural and functional changes that underlie this condition is important in developing interventions that would prevent the evolution to dementia. Neuroimaging structural and resting state studies comparing SCD individuals with healthy controls (HC) have reported inconsistent results. Therefore, to identify core regions affected in SCD, meta-analyses of grey matter (GM) changes and resting state brain activity alterations were performed. Studies employing whole-brain voxel-based morphometry and, respectively, examining resting state brain activity using functional MRI, PET or SPECT were retrieved through a comprehensive search using the PubMed, Embase, and Web of Science databases. Activation likelihood estimation (ALE) method was used to perform coordinate-based meta-analyses. Compared to HC, SCD individuals show grey matter loss in regions including the left middle/superior frontal gyrus (BA 10), right cingulate gyrus / medial frontal gyrus, right lingual gyrus / cuneus and precuneus. They also show hypometabolism in the right inferior/superior temporal gyrus (BA 21) and right hippocampus / parahippocampal gyrus. The results reveal potential biomarkers for SCD and therapeutic targets for brain stimulation interventions to prevent progression towards MCI or AD.