The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, stands out as a prominent neurogenic region in the adult brain of many mammals. Our aim is to comprehend the structural organization and cellular composition of the V-SVZ in the juvenile swine brain (3-5 months), providing new insights into neuroblasts migration. Combining immunohistochemistry techniques with transmission and scanning electron microscopy, we redefined the cytoarchitecture of the swine V-SVZ, previously described by other authors, identifying four cellular layers. Layer 1 features a pseudostratified epithelium of GFAP+ ependymal cells, with cilia and microvilli extending into the ventricle, often surrounding serotoninergic supraependymal axons. Subependymal layer 2 is composed of astrocytic and radial expansions and exhibits ocasional clusters of DCX+ cells displaying microtubules, suggesting a migratory nature. Layer 3 is subdivided into a deeper low cell density layer (3A), with abundant myelinic axons and scattered DCX+ clusters and a high cell density layer (3B), hosting substantial groupings of DCX+ migratory-like cells. In sagittal sections, these cells form long chains parallel to the ventricular surface, that are headed caudo-rostrally towards the olfactory bulb through the rostral migratory stream, but also diverge towards other regions like the piriform cortex. The recent description of immature cells in gyrencephalic mammals, including the human, increases the interest in neuroplasticity and neurogenesis in large-brain species. The swine V-SVZ layered structure resembles to that of the human, where DCX+ chains persist until 18 months of age, providing a new model for embryonic development and postnatal plasticity in gyrencephalic brains.