PCD mice suffer the postnatal death of cerebellar Purkinje neurons and mitral cells of the olfactory bulb (OB). They are also defective in IGF1, but little is known about other neurotrophic factors, which may act as neuroprotective molecules.The expression of different neurotrophic factors (IGF1, BDNF, VEGF-A and VEGF-B) was analyzed by qPCR and ELISA around cerebellar and bulbar degenerations of PCD mice. Then, we applied two different therapies depending on the affected region.1. We refined healthy bone marrow transplants to reduce the degeneration of mitral cells. PCD mice were transplanted with 7.5 million bone marrow stem cells, supplemented with genetically modified hematopoietic cells for overexpressing the Igf1 gene. At P150, animals were sacrificed and their olfactory bulbs were analyzed by immunofluorescence and quantitative PCR.2. Recombinant human IGF-1 or VEGF-B were administered in PCD mice depending on their expression around Purkinje cell loss. After motor tests, cerebella were analyzed at P25 or P30 by immunofluorescence.Only IGF1 and VEGF-B presented variations around the neurodegenerative processes of PCD mice. Concerning OB, the transplantation of a genetically modified healthy bone marrow stopped the mitral cell loss of PCD mice. IGF1-enriched transplants changed the inflammatory pattern and prevented DNA damage. Regarding cerebellar degeneration, we observed an improvement in both motor coordination and Purkinje cell survival in PCD mice administered with VEGF-B. qPCR analyses revealed an inhibition of the intrinsic pathway of the apoptotic process.In conclusion, neurotrophic factors are very suitable candidates to develop different neuroprotective therapies.