Neuromodulation technologies became the safe and effective alternative to treat psychiatric and neurological disorders.We aimed to evaluate the effects of the non-invasive vagus nerve stimulation on psychoemotional state.11 right-handed male volunteers aged 18-22 years participated in the 1st (EEG) study (6 persons-taVNS group and 5-SHAM).62 healthy volunteers 18-49 years old were recruited for 2nd (HRV) study (26-VNS group and 22–Sham).The set of 4 VNS (BrainPatch) was performed at intervals of 3 days with monitoring of HRV and psychometrics.EEG was registered during the rest state (3 min, closed eyes condition).We detected beneficial changes in the psychoemotional state of the respondents.The increase of vagally mediated parameter RMSSD and decrease of LF/HF-ratio has reflected the activation of parasympathetic nervous system (PNS) during stimulation. HRV effects of VNS turned out to be short-term, which was manifested in a drop in the value immediately after the stimulation. EEG analysis data indicate a long-term effect of VHS.After 4th VHS session we observed increase of the alpha and beta rhythms (generalised growth in frontal and posterior cortex) and gamma activity (frontal area).The observed effects may indicate the improvement of mental processes and creative thinking (attention, information processing and memory storage).The increase of the ratio of beta/alpha rhythms reflected the enhancement of the activation level.We suggest that VHS has a normalizing effect on the psychoemotional state shifting “sympatho-vagal balance” to the functional optimum.EEG data showed the prolonged stimulating effect on the brain processes related to the cognitive functioning while attenuating the stress impacts at the same time.