Understanding the dynamic interplay between neuromodulatory systems and neuronal circuit dynamics is crucial for deciphering the underpinnings of complex behaviors. Noradrenergic signaling is widespread throughout the body and the brain and plays a pivotal role in the implementation of physiological processes and brain network configuration across arousal states. Yet, unraveling the causal relationship between norepinephrine release and concomitant neuronal dynamics poses a formidable challenge due to the intrinsic coupling of noradrenergic activity with behavioral changes.To resolve this conundrum, we utilize large-scale electrophysiology recordings, coupled with the simultaneous monitoring and manipulation of norepinephrine release and locus coeruleus activity, to investigate the impact of noradrenergic modulation in shaping thalamic, hippocampal, and cortical dynamics across behavioral states in behaving mice. This integrative approach allows us to correlate intrinsic or experimentally imposed noradrenergic release with the emergence of neural ensemble dynamics across the circuit.We characterize the relationship between norepinephrine release and behavioral dynamics, unveiling a tight coupling of norepinephrine release with behavioral micro- and macro-states spanning the arousal and valence axes.Furthermore, our findings reveal state-dependent alterations in firing rates, synchrony, and network dynamics, reflecting the dynamic modulation of thalamic, hippocampal, and cortical circuits by noradrenaline and suggesting a multifaceted role of noradrenergic signaling in shaping information processing across these brain regions.Our results underscore the significance of noradrenergic neuromodulation in orchestrating coordinated activity within and across neural circuits, highlighting its role in shaping cognition and behavior, and providing insights into the mechanisms by which noradrenergic modulation regulates brain states.