ePoster

A novel neural stimulation mechanism on cellular level without faradaic current

Bingdong Changand 2 co-authors

Presenting Author

Conference
FENS Forum 2024 (2024)
Messe Wien Exhibition & Congress Center, Vienna, Austria

Conference

FENS Forum 2024

Messe Wien Exhibition & Congress Center, Vienna, Austria

Resources

Authors & Affiliations

Bingdong Chang, Xiyuan Liu, Anpan Han

Abstract

Neural stimulation is an important technology not only for fundamental neuroscience studies, but also for therapeutic purposes and advanced devices like neuroprosthetics and brain machine interfaces. To achieve an accurate stimulation on a cellular level, invasive devices are normally used especially for deep brain stimulation. A widely used stimulation mechanism is by injecting current with microelectrodes, which has the limitation of tissue damage on the electrode/electrolyte interface. Another stimulation mechanism is based on microscale magnetic field, which requires complicated fabrication processes. Here we introduce a novel stimulation strategy based on locally enhanced electric field. The device is based on a sharp metallic tip covered by insulating material, and intensified displacement current can be generated close to the tip end with an AC input signal, therefore activating neurons. We have developed physical models and performed numerical simulation to verify the feasibility of this method. Charge densities are quantified based on tip geometries and input signals, which is on the level of 100 µC/cm2, above the threshold charge density for a wide range of neural stimulation purposes. We also provide design guidelines for manufacturing the devices in future work. Compared with other stimulation mechanisms, this new strategy has following advantages: minimized tissue damage as no faradaic current is flown through the targeted tissue; cellular-level stimulation accuracy within few micrometers from the tip end; selectivity based on orientation of neurons; low fabrication complexity for high-throughput productions. We expect this novel stimulation method can pave the way for new possibilities in neuroscience and neuroengineering.

Unique ID: fens-24/novel-neural-stimulation-mechanism-cellular-831bee94