Common Ground: Both studies investigate neural circuits in the hypothalamus and their role in behavioral regulation, particularly in the context of energy homeostasis and anxiety-related behaviors.
Key Differences: The current study focuses on leptin receptor-expressing neurons in the lateral hypothalamus and their role in anxiety and anorexia nervosa, while the recommended study examines AgRP neurons in the arcuate nucleus and their influence on body weight, lifespan, and behavior under calorie restriction.
Methodologies: The current study uses calcium imaging, opto- and chemogenetics in freely behaving mice; the recommended study employs the AgRPDTR mouse model to impair AgRP neuronal function and assess behavioral and physiological changes.
Complementary Aspects: The current study provides insights into anxiety modulation by leptin in anorexia nervosa, while the recommended study offers a broader understanding of how disruptions in hypothalamic circuits affect energy balance and behavioral patterns in a sex-dependent manner.
Potential Impact: Combining insights could elucidate neurobiological mechanisms underlying eating disorders and related anxiety, informing targeted interventions.

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