In a recent study in rodents in our team, we showed that sonogenetic therapy can be applied to stimulate the visual cortex (V1) at a high spatiotemporal resolution with ultrasound following the expression of the MscL mechanosensitive ionic channel. Moreover, we proved that sonogenetic activation of V1 can generate visual perception using an associative learning test.To develop sonogenetics as a vision restoration therapy the next step is to prove visual perception via sonogenetic stimulation in non-human primates (NHPs).Methods: In consequence, we proceeded to obtain retinotopic maps of NHP’s V1 using functional ultrasound imagery. These retinotopic maps were used for viral injection planification of MscL in NHPs V1. After one month of transfection, we recorded neuronal activities using ECoGs to verify transfection functionality. Finally, NHPs are being trained to assess if visual perception could be evoked under sonogenetic stimulation.Results: Retinotopic maps were made on multiple planes covering great percentage of the recording chamber. We made a projection of the results of every session in order to get a mean retinotopic characterization by plane. Combining ECoG recordings and ultrasound stimulation, we were able to visualize the focal spot of ultrasound stimulation. We noticed that under several specific conditions of ultrasound stimulation, monkeys were performing some eye movements toward the expected location.Together, these promising preliminary results suggest that sonogenetic stimulation of the visual cortex could generate a visual perception on NHPs. Further results and analyses are needed to complete these therapeutical approach.