Memory mechanisms remain elusive in their system implementation. Previous research, combining fMRI and electrophysiology in anaesthetized rats, has shown that synaptic plasticity in the Dentate Gyrus (DG) orchestrates coordination in memory-related brain networks. By employing graph theory and pharmacogenetic tools, we further unveiled a hierarchy in system-level communication that highlighted interactions between the hippocampus, nucleus accumbens, and prefrontal cortex. However, whether a similar functional architecture supports brain coordination in awake behaving animals remains unknown.Using TRAP2-tomato mice (n=7) in a memory task involving novel object location associations, we labeled and analyzed c-Fos+ cells in 117 regions segmented from the Allen Brain Atlas, constructing correlated networks. Descriptive statistics revealed a very similar structure of c-Fos+ networks labelled during the encoding versus retrieval of memories, with distinct nodes fulfilling relevant roles in communication based on the number or distribution of connections. Utilizing connectivity data from Allen and a balanced colouring repair algorithm we generated a directed network that reproduces our observed correlation. We then performed a topological analysis of this network and it revealed a core network composed of as much as 75% of all brain regions studied, coordinated by as few as 16% of the anatomical links. Connectivity in this minimal memory engram points to a reduced set of cortical regions, in addition to the hippocampus, with a predicted disproportionate influence in global coordination. Ongoing experiments are dedicated to testing these predictions.