The auditory loss is associated with increased cognitive deterioration and even dementia, including Alzheimer's Disease (AD). However, the relation between the cause of the auditory loss and the mechanism during AD is still unknown. One hypothesis is that social isolation after hearing loss could facilitate dementia. Still, it is also believed that AD itself could cause alterations in the auditory pathway and this alteration promotes cognitive deterioration. The auditory signal is transmitted along the auditory pathway in the form of action potentials through the auditory nerve and across the different neuronal nuclei of the auditory pathway. For transmitting the auditory signal, voltage gate potassium ion channels are essential. Alteration in these channels can aggravate AD or vice-versa, alteration provoked by AD in this channel can turn into hearing loss. In this work, we show that there is an alteration in Kv1auditory brainstem response.1 and Kv3.1 potassium channels in the auditory cortex of 6-month-old AD transgenic mice compared to control mice. Moreover, we also show that there is an auditory brainstem response alteration in the auditory pathway of these transgenic mice compared to the control group. These are preliminary results that show the mechanism underlying hearing loss and AD and provide a new insight for future studies.