Obesity and metabolic diseases are a top priority challenge for health systems. Monitoring changes in the body’s energy levels is a task of the hypothalamus which integrates the actions of peripheral hormones and nutrients with neural information. Among the cells involved, tanycytes play a key role. They are glial cells that line the third ventricle and mediate information about changes in the circulation to various hypothalamic nuclei. They regulate important neuroendocrine functions such as food intake and energy balance. Although tanycytes are known to integrate external and internal signals, the cellular organelles through which they sense these cues remain unknown. Primary cilia are one such compartment crucial for perceiving signals, and they are indeed present in tanycytes. However, the function of tanycytic cilia is still unclear. We hypothesize that cilia may act as antennae for tanycytes, sensing nutrients or hormones and transmitting metabolic information to neurons. We found that cilia exhibit morphological differences depending on the tanycytic subtypes, suggesting different functions of these cilia. In primary cultures of tanycytes, we set up a model for in vitro impairment of ciliary function, and analyzed how this functional defect could affect sensing of external stimuli, such as increased ATP concentration. We found that tanycilia disruption decreases the ATP-induction of [Ca2+]i. This project aims to characterize tanycytic cilia morphology and identify their functions, primarily in the regulation of metabolism. The discovery of tanycytic cilia’s roles in integrating peripheral signals to regulate neuroendocrine functions holds promise for understanding and treating metabolic disorders.