Neuronal oscillations can be used to understand brain plasticity phenomena during trauma. The oscillations of local field potentials (LFP) represent the phasing of the membrane potentials of different types of neurons at both the cortical and subcortical levels. In this project, we have studied the plasticity process that occurs in the primary visual cortex following monocular enucleation in mice using LFP recordings. To elicit a response in V1, animals are subjected to protocols of visual, auditory, and somatosensory stimulation while the electrode remains in the same location (figure). We have analyzed the LFP data using EEGLab to study the dynamics of the waves recorded in V1 during stimulation protocols. The plasticity process that occurs after monocular vision loss in mice involves a shift between visual and auditory tasks of V1 neuron populations, which has been evident in terms of dominance in Beta (β) wave power. In the physiological state, this dominance is evoked with visual stimulation, but after two weeks of enucleation, this β-waves dominance is evoked by auditory stimulation (figure). During the experiments, we proposed a complementary study on the possibility that the visual cortex in mice is multisensory, as seen in the results obtained through LFP recordings. Therefore, in 5 control animals, we recorded single-neuron activity in V1, resulting in an increase in spikes following visual, somatosensory, or auditory stimulation (figure). Caption: Histogram of maximum ERSP values control(orange) and enucleation(blue). Middle: Stimulus and recording orientation (left), LFP recording (right). Below: Spike histograms during visual, somatosensory, and auditory stimulation.