After cerebral damage such as stroke or traumatic injuries, regenerative angiogenesis and neurogenesis occur almost simultaneously, suggesting intimate links between them. However, the mechanisms by which both processes interact are not well understood. In this work, we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic injury. To this end, we used the zebrafish as a model of brain repair. First, using the transgenic Tg(fli:GFP) zebrafish to visualize endothelial cells, we analyzed regenerative angiogenesis and neural stem cell proliferation (neurogenesis) from 1 to 14 days post-lesion (dpl) through immunohistostaining experiments. We reported that after brain damage, the expression of the fli transgene, the number of blood vessels, and their width were transiently increased in the first days as well as vascular endothelial growth factors (vegfaa and vegfbb) being mainly overexpressed in neurons. In parallel, neural stem cell proliferation was also induced peaking from 3 to 5 dpl. By modulating the vegf signaling through anti-angiogenic drugs (Tivozanib) and Vegf injection at the lesion site, we demonstrated that blocking vegf receptors impairs microglia recruitment and subsequently both neurogenic and angiogenic processes. In contrast, the injection of Vegf favors microglia activation and regenerative processes, while the inhibition of microglia after brain lesion impaired these brain repair mechanisms. In conclusion, we showed that regenerative processes are associated during brain repair in zebrafish. In this context, microglia appear as a key player in the control of regenerative processes making this study a step closer to the promotion of brain repair after injuries.