Sensory information is first processed by various thalamic nuclei before reaching the pallium in amniotes where it is used for higher-order computations such as encoding new memories. In teleost fish, the dorsal thalamic nuclei, believed to be analogous to the amniote thalamus, projects primarily to the subpallium. However, the major diencephalic input to the pallium originates from the preglomerular nucleus (PG), suggesting that it may perform analogous functions to the amniote thalamocortical pathway. To examine this, we first mapped the anatomical inputs to the zebrafish PG and showed that it receives inputs from multiple sensory and limbic forebrain and midbrain nuclei, resembling the thalamic-equivalent in other species. Using two-photon Ca2+ imaging in juvenile zebrafish, we showed that PG neurons exhibit topographically organized resting state activity and spatially organized PG neurons preferentially respond to distinct sensory stimuli (light vs mechanical vibrations). Calcium imaging of PG axon terminals in the fish pallium revealed that different sensory modalities elicit responses in mutually exclusive and topographically distinct pallial zones. These results were further validated by ex-vivo micro-stimulations experiments where PG activates topographically restricted zones in the dorsal lateral (hippocampal analogue) and dorsal medial (amygdala analogue) pallium. In contrast, we observed that sensory responses of pallial neurons exhibit mixed selectivity to multiple sensory modalities, while the toparchical organization of pallial PG axonal responses were largely sensory driven. Our results revealed that like thalamocortical systems in mammals, the zebrafish pallium integrates sensory information from the thalamic-like PG and can potentially use this for higher cognitive operations.