Resilience, defined as the ability to positively adapt to stress, is intricately linked to various neurobiological systems, with the noradrenergic (NE) system being a key player. As a primary modulator of the stress response, the NE system also holds significance in brain development, particularly during critical periods. Recent findings in both mice and humans have underscored its role in promoting resilience in the aftermath of stressful events during adulthood. Nonetheless, limited evidence exists regarding its involvement in resilience following child abuse.`To address this inquiry, we employed immunohistochemistry on post-mortem human Locus Coeruleus (LC) tissues obtained from individuals with depression and a history of child abuse (DS-CA), those with depression without such history (DS), psychiatrically healthy individuals with a history of child abuse (RES-CA), and those without any psychiatric history (CTL). Our investigation revealed distinct variations in the density of LC-noradrenergic (LC-NE) neurons among these groups.Taking a step further, we conducted transcriptomic sequencing specifically on 300 noradrenergic cells within human post-mortem tissues from the same subject groups. Our analysis unveiled unique clusters of genes that were either upregulated or downregulated in the Locus Coeruleus (LC), demonstrating specific molecular signatures associated with depression with and without child abuse, as well as resilience following child abuse.This study represents a pioneering effort in investigating the molecular signatures of resilience within human post-mortem tissues. Our findings underscore the involvement of the LC-NE system in resilience following experiences of child abuse.