Some animals use the strategy, known as hibernation, to survive harsh environments, such as extreme thermal challenges and food scarcity, by reducing metabolism and core body temperature. Recent work has shown that activation of Qrfp neurons in the preoptic area of the hypothalamus (POA) can induce a hibernation-like state in non-hibernators such as mice, termed Q-neuron-induced hypothermia and hypometabolism (QIH) (Takahashi et al., Nature, 2020). During QIH, the mice show hypothermia with low systemic oxygen consumption. Interestingly, they show immobile behaviours, such as hibernation and anesthesia, in which the animal typically loses its sensation. However, it is unclear how the sensory perception is regulated during QIH. In this study, we performed the in vivo calcium imaging to identify the cell type-specific manipulations in the somatosensory cortex in response to tactile stimulation while mice were awake, anaesthetized or under QIH induced by using DREADD to chemogenetically activate the Qrfp neurons. We found that the QIH mice were able to respond to the hind paw pinch, just as they did when they were awake, suggesting that mice stay tune to the external stimulus while they are under low energy demand. In vivo calcium imaging combined with cell type-specific promotor-driven expression of the calcium indicator revealed that cells in the somatosensory cortex have heterogeneous response to the hind paw pinch. In particularly,astrocytes were more activated during the QIH recording than during the awake recording. These results show that the mice utilize a unique strategy to process the sensory information during QIH.