We aimed to investigate the association between WC and all-cause mortality of Parkinson disease (PD) using Korean National Health Insurance Service cohort data. Patients newly diagnosed PD were selected using the ICD-10 code (G20) and rare intractable disease registration code (V124). Anthropometric data including WC and body mass index (BMI) were obtained from the health screening data. We classified WC into following five categories: <70, 70–80, 80–90, 90–100, and ≥100 cm in males; <65, 65–75, 75–85, 85–95, ≥95 cm in females. The Cox proportional hazards model was used to assess all-cause mortality risk by WC. Among 22,118 patients with PD, 9,179 (41.50%) died during the 10-year follow-up period. WCs of < 70 cm among males and < 65cm among females were significantly associated with increased mortality in patients with PD (HR=1.19, 95% CI, 1.05–1.34). Before adjustment of BMI, mortality risk was significantly decreased at WCs of ≥ 80 cm among males and ≥ 75cm among females. However, after adjusting for BMI, WC of ≥ 90 cm among males or ≥ 85cm among females, which is criteria for central obesity, increased mortality risk significantly (M 90-100, F 85-95: HR=1.13, 95% CI, 1.05–1.22; M >100, F >95: HR=1.50, 95% CI, 1.33–1.68). Central obesity was a significant risk factor for mortality in PD after adjusting BMI. Our results suggest that management of WC is crucial for PD patients, and BMI should be considered for WC management plan for mortality in PD.