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Theta oscillations as a mechanism for communication between cortical sensory areas, Perirhinal cortex and Hippocampus during sensory detection and memory recollection

Thijs R. Ruikes, Julien Fiorilli, Gerjan Huis in 't Veld, Jan G. Bjaalie, Ingrid Reiten, Cyriel Pennartz

Date / Location: Tuesday, 12 July 2022 / S05-446
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Memory consolidation and recall have been suggested to be driven by coordinated oscillatory activity, such as Hippocampal (HC) theta oscillations, of neuronal ensembles during memory-guided, spatial behaviour. Although multiple studies have demonstrated entrainment of neural assemblies on the hippocampal theta cycle (Vinck et al., 2016) , few investigations have investigated this phenomenon in brain-wide circuits by means of simultaneous multi-area ensemble recordings from distant regions. Additionally, it remains debatable which behavioural parameters most prominently relate to brain-wide coordinated oscillatory entrainment (Mizuseki & Buzsaki, 2014). Here we investigate coherency driven by oscillations between HC and the Visual (V2L), Somatosensory Barrel (S1BF) and Perirhinal (PER) cortices. These areas are interlinked trough anatomical projections and thought to form a cortical hierarchy facilitating the incorporation of sensory information into episodic memory (van Strien et al., 2009). Using a 36-tetrode hyperdrive, we recorded neural activity from four areas (V2, S1BF, PER, HC) simultaneously in freely behaving rats doing a multimodalโ€“two alternative forced choiceโ€“object recognition task on a T-maze. The rats were shown one out of two objects under either tactile, visual or multimodal conditions and were rewarded if they responded on the arm of the T-maze associated with the object. Using the pairwise phase consistency we found increased spike-field coherency between HC theta cycles and neurons recorded in V2L (n=310), BR (n=118), PER (n=194) and HC (n=139), during behavioural epochs of sensory detection and memory recollection. Our results highlight the differences in processing between areas S1BF,V2L, PER and HC during the utilization of episodic memory.

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