Learning and decision making are intertwined processes in many everyday situations. One example is when you decide where to have lunch: should you go to the nearby coffee shop or to the university cafeteria? Learning depends on choice, because you can learn which option you prefer by trying each option repeatedly, and decision making depends on learning, because you eventually want to select the option you have learned you like best. Uncertainty plays a key role in both learning and decision making, especially when the environment is not stationary. In the CEA-funded EXPLORE+ collaborative project, we are interested in characterizing the neural representation of uncertainty and value that emerge from learning and guide decisions. Our approach follows a deep phenotyping approach, attempting to characterize each subject with a large multimodal dataset. We collected data from 16 participants who participated in one behavioral session, two 7T fMRI sessions, and two MEG sessions. The large number of trials allows us to estimate and test different computational models of the decision and learning processes. The 7T MRI and MEG data provide access to the topographical organization of neural representations and their dynamics, respectively, to better understand learning and decision making. One postdoc is currently working on the fMRI data, and we are looking for another postdoc for the MEG dataset. Both postdocs will work together to perform analyses informed by both modalities. The EXPLORE+ project will continue with another previously funded project called BrainSync, which will collect data from 11.7 fMRI and intracranial recordings using the same task, providing an opportunity to extend the current work.

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