This is a joint postdoctoral position between Prof David Sharp’s laboratory (based at the UK DRI CR&T Centre), focused on the long-term neurodegenerative effects of traumatic brain injury, and Dr Marc Aurel Busche’s laboratory (based at the UK DRI at UCL), which has been at the forefront of developing tools permitting multi-scale and multi-modal monitoring of large-scale neural circuits in models of dementia.

The main goal of the project will be to examine the effects of traumatic brain injury on neuronal circuit and neurovascular function in vivo, how this may accelerate molecular and cellular processes linked to Alzheimer’s Disease (the most common cause of dementia) and determine whether the pathophysiology is reversible. The project will involve recording neuronal activity and vascular dynamics using state of the art two-photon and electrophysiological (Neuropixels) methods and also linking this to available human datasets (e.g., fMRI).

The successful candidate will be self-directed with excellent research skills, and capable of working collaboratively within a team of international multidisciplinary researchers, while displaying independent thinking and initiative. This is an outstanding opportunity to work independently on a high impact, state-of-the-art collaborative and cross-species project in a stimulating and vibrant research environment.

The post is available immediately and is funded by a UK DRI Cross-Centre Postdoctoral award for two years in the first instance.

For more information, and to apply please see: https://bit.ly/3qOulVp

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