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Seminar✓ Recording AvailablePhysics of Life

Flow, fluctuate and freeze: Epithelial cell sheets as soft active matter

Silke Henkes

Prof

University of Bristol

Schedule
Wednesday, September 16, 2020

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Schedule

Tuesday, September 15, 2020

11:30 PM America/New_York

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Host: NYU Soft Matter Seminar

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Event Information

Domain

Physics of Life

Original Event

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Host

NYU Soft Matter Seminar

Duration

70 minutes

Abstract

Epithelial cell sheets form a fundamental role in the developing embryo, and also in adult tissues including the gut and the cornea of the eye. Soft and active matter provides a theoretical and computational framework to understand the mechanics and dynamics of these tissues.I will start by introducing the simplest useful class of models, active brownian particles (ABPs), which incorporate uncoordinated active crawling over a substrate and mechanical interactions. Using this model, I will show how the extended ’swirly’ velocity fluctuations seen in sheets on a substrate can be understood using a simple model that couples linear elasticity with disordered activity. We are able to quantitatively match experiments using in-vitro corneal epithelial cells.Adding a different source of activity, cell division and apoptosis, to such a model leads to a novel 'self-melting' dense fluid state. Finally, I will discuss a direct application of this simple particle-based model to the steady-state spiral flow pattern on the mouse cornea.

Topics

active brownian particlesapoptosiscell divisioncorneal epithelial cellsepitheliaepithelial cell sheetslinear elasticitymechanical interactionssoft active mattersoft mattervelocity fluctuations

About the Speaker

Silke Henkes

Prof

University of Bristol

Contact & Resources

Personal Website

www.bristol.ac.uk/maths/people/silke-e-henkes/index.html

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