The Aging Brain Initiative (ABI) is an interdisciplinary effort by MIT focusing on understanding neurodegeneration and discovery efforts to find hallmarks of aging, both in health and disease." "The Alana Down Syndrome Center (ADSC) aims to deepen knowledge about Down syndrome and to improve health, autonomy and inclusion of people with this genetic condition." "The ABI and the ADSC have joined forces for this year's symposium to highlight how aging-related changes to the brain overlap with neurological aspects of Down syndrome. Our hope is to encourage greater collaboration between the brain aging and Down syndrome research communities.