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Dr.
Salk Institute for Biological Studies
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Schedule
Tuesday, October 11, 2022
4:00 PM Europe/Lisbon
Domain
NeuroscienceHost
Brain-Body Interactions
Duration
70 minutes
Animals modify their behavioral outputs in response to changes in external and internal environments. We use the nematode, C. elegans to probe the pathways linking changes in internal states like hunger with behavior. We find that acute food deprivation alters the localization of two transcription factors, likely releasing an insulin-like peptide from the intestine, which in turn modifies chemosensory neurons and alters behavior. These results present a model for how inter-tissue signals to generate flexible behaviors via gut-brain signaling.
Sreekanth Chalasani
Dr.
Salk Institute for Biological Studies
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