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Neural Mechanisms Rhythmic Motor

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SeminarPast EventNeuroscience

Neural mechanisms of rhythmic motor control in Drosophila

John Tuthill

University of Washington, Seattle, USA

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Thursday, May 15, 2025

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Thursday, May 15, 2025

10:30 AM Europe/Zurich

Host: NeuroLeman Network

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Abstract

All animal locomotion is rhythmic,whether it is achieved through undulatory movement of the whole body or the coordination of articulated limbs. Neurobiologists have long studied locomotor circuits that produce rhythmic activity with non-rhythmic input, also called central pattern generators (CPGs). However, the cellular and microcircuit implementation of a walking CPG has not been described for any limbed animal. New comprehensive connectomes of the fruit fly ventral nerve cord (VNC) provide an opportunity to study rhythmogenic walking circuits at a synaptic scale.We use a data-driven network modeling approach to identify and characterize a putative walking CPG in the Drosophila leg motor system.

Topics

BMI Seminarcentral pattern generatorsconnectomesdrosophilaleg motor systemlocomotionrhythmic activitysynaptic scaleventral nerve cordwalking circuits

About the Speaker

John Tuthill

University of Washington, Seattle, USA

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@NeuroLeman

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