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SeminarPast EventNeuroscience

Spontaneous activity competes with externally evoked responses in sensory cortex

Golan Karvat

Dr.

Diester lab, University of Freiburg, Germany

Schedule
Thursday, November 25, 2021

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Schedule

Thursday, November 25, 2021

5:30 PM Europe/Berlin

Host: Bernstein SmartSteps

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Event Information

Domain

Neuroscience

Original Event

View source

Host

Bernstein SmartSteps

Duration

30 minutes

Abstract

The interaction between spontaneously and externally evoked neuronal activity is fundamental for a functional brain. Increasing evidence suggests that bursts of high-power oscillations in the 15-30 Hz beta-band represent activation of resting state networks and can mask perception of external cues. Yet demonstration of the effect of beta power modulation on perception in real-time is missing, and little is known about the underlying mechanism. In this talk I will present the methods we developed to fill this gap together with our recent results. We used a closed-loop stimulus-intensity adjustment system based on online burst-occupancy analyses in rats involved in a forepaw vibrotactile detection task. We found that the masking influence of burst-occupancy on perception can be counterbalanced in real-time by adjusting the vibration amplitude. Offline analysis of firing-rates and local field potentials across cortical layers and frequency bands confirmed that beta-power in the somatosensory cortex anticorrelated with sensory evoked responses. Mechanistically, bursts in all bands were accompanied by transient synchronization of cell assemblies, but only beta-bursts were followed by a reduction of firing-rate. Our closed loop approach reveals that spontaneous beta-bursts reflect a dynamic state that competes with external stimuli.

Topics

LFPbeta-bandbeta-burstburst-occupancycomputational neurosciencecortexfiring-ratelocal field potentialsoscillationsresting-state-networksensory cortexsensory evoked responsessomatosensoryspontaneous activityvibrotactile detection

About the Speaker

Golan Karvat

Dr.

Diester lab, University of Freiburg, Germany

Contact & Resources

Personal Website

www.optophysiology.uni-freiburg.de

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