Seminars

Mark Harnett presents work on how synaptic organization, nonlinear dendritic processing, and neuronal activity patterns interact to support computation, flexibility, and learning in the adult mammalian neocortex. The Brain and Cognitive Sciences colloquium is followed by a reception.

Bowen Li explains how ionizable lipids are designed for lipid nanoparticles that deliver messenger RNA. The seminar covers combinatorial and machine-learning-guided design, four-component reactions for rapidly producing lipid libraries, and barcoded screening in living systems to identify formulations targeting organs and cells, including lungs, T cells and tumours. It then examines applications of AI-guided nanoparticle platforms to mRNA therapeutics. Li is an Associate Professor and Canada Research Chair at the University of Toronto's Leslie Dan Faculty of Pharmacy. Online via Zoom. Thursday 24 September 2026, 11:00–12:00 Eastern Daylight Time (America/New_York; UTC−4). Use Join via Zoom on Western University's event page. The stated audience includes researchers, students, alumni and the general public. Organized by Western University's Western Bioinformatics Research Seminar.

Florian Marquardt surveys approaches to reducing the energy and computational cost of neural networks by implementing their functions in physical devices. The central question is how experiments can efficiently determine updates to adjustable parameters, allowing the hardware itself to learn. Examples include learning through time reversal, obtaining nonlinear computation from linear optical scattering, and training analog quantum simulators as neuromorphic systems. The seminar is available in person and through the registration link on the organizer’s event page.

Qihao Ye examines practical, affordable ways for individual mathematicians to use AI in literature searches, proof development and verification. The talk identifies seven recurring failure modes and introduces the open-source QED multi-agent system designed to address them. A case study on constructing Carleman weights for wave equations on the half-line shows how automated search can be combined with a researcher’s mathematical insight and rigorous checking. The organizer links both the implementation and the accompanying research paper. Online via Rutgers DIMACS Zoom. Wednesday 23 September 2026, 10:00–11:00 EDT (America/New_York; UTC−4). Use the Zoom link and passcode on the official event page. Organized by the DIMACS AI and Mathematics Seminar. This listing advertises the verified remote attendance option.

ISTA Lecture by Klaus Robert Müller (TU Berlin & Korea University, Seoul) on how machine learning and AI enable scientific research, particularly in medicine and chemistry, and on explainability techniques for extracting understanding from machine learning models.

Bryce Mander presents research on early sleep biomarkers associated with Alzheimer's disease pathophysiology and memory impairment. The William C. Dement Seminar connects sleep and circadian neuroscience with neurodegeneration, cognition and clinically relevant approaches to detecting disease-related change.

Rani Borbara presents brain-wide recordings from more than 150 freely moving C. elegans to examine how anatomical connectivity becomes functional organization during behavior. Cross-animal models map cell-class conditional dependencies and test how synapses, gap junctions, neuromodulation and shared brain states shape circuit dynamics.

Stanford Neurosciences Seminar Series talk by Emery Brown (Massachusetts Institute of Technology, Neuroscience Statistics Research Lab) on deciphering the dynamics of the unconscious brain under general anesthesia, hosted by the Wu Tsai Neurosciences Institute.

Daphna Shohamy and Ashok Litwin-Kumar bridge experimental and computational neuroscience to explain how the brain assigns significance to memories, how dopamine shapes memory-guided decisions, and how bodily signals influence learning. Isabel Low moderates a public discussion and question session.

Omar M. Yaghi examines how reticular chemistry changes the scale and diversity of materials that chemists can design. By joining molecular building blocks into extended structures, researchers have developed large families of metal–organic frameworks and covalent organic frameworks with tunable internal spaces and functions. The lecture asks how artificial intelligence and robotics could accelerate the preparation and exploration of these materials, moving chemical discovery from scarcity toward abundance. Yaghi connects this approach to carbon capture and the collection of water from air, building on design principles for nanoporous frameworks and their applications in gas storage and separation. The discussion extends the metal–organic framework research recognised by the 2025 Nobel Prize in Chemistry into current methods for discovery and environmental applications.

Tal Linzen, an associate professor of linguistics and data science at New York University and a research scientist at Google, will speak in MIT's Siegel Family Quest for Intelligence seminar series. His work combines behavioral experiments and computational methods to study language learning and comprehension, alongside large-language-model post-training, evaluation, and interpretability.

Yuko Munakata presents evidence challenging capacity-only accounts of self-control and explains how experience, effort, and expected payoff shape executive-function engagement and later outcomes.

Zohar Ringel of the Hebrew University of Jerusalem presents a renormalisation-group approach to deep learning based on neural-network field theories. The seminar examines scaling laws, the removal of non-learnable field modes, benign overfitting and open questions about feature learning. The confirmed Quantum Matter seminar takes place in the Bob Room at Perimeter Institute on 8 September 2026, from 15:30 to 17:00 Toronto time.

Nick Turk-Browne presents research using infant functional MRI to investigate how the hippocampus supports learning and memory early in life. The seminar connects neural development, memory formation and infantile amnesia through new methods for studying awake infants.

Margaret Livingstone of Harvard Medical School presents in Princeton Neuroscience Institute's public seminar series. Livingstone's laboratory studies how visual recognition occurs in the primate brain using behavior, brain imaging, and electrophysiology.

Michelle M. Li examines how computational analyses can preserve the biological context of a proposed treatment, including cell type, disease state, genetic background and patient characteristics. She introduces Medea, an AI system that combines biological software, predictive models and literature retrieval while checking intermediate steps and reconciling evidence. The seminar presents evaluations involving cell-specific target selection, cancer-cell synthetic lethality and immunotherapy response. A separate yeast experiment tests predictions against previously unpublished measurements of gene-pair interactions under DNA-damaging treatments. The research addresses whether an agent can transfer useful evidence between contexts while recognizing when that transfer is unsupported. Reported comparisons cover predictive performance, computational failures and the ability to abstain. This recording retains the original seminar date.

Large recurrent networks are important models in several fields, including neuroscience, machine learning, physics, and applied mathematics. Yet their dynamics are difficult to study directly, because high-dimensional nonlinear systems can exhibit rich behavior that is hard to summarize in terms of individual trajectories. In this talk, I will discuss an approach that seeks to understand such dynamics through the structure of the network’s equilibria. I will focus on a random balanced network of threshold-linear units that undergoes a transition from a single stable equilibrium to extensive chaos as the disorder strength crosses a critical value. Using a combination of Kac–Rice theory, replica calculations, numerical root-finding, and dynamical mean-field theory, we show that the chaotic regime contains an exponentially large number of equilibria. These equilibria are all saddles, but with only a fractionally small number of unstable directions. Surprisingly, despite the completely random connectivity, the equilibria are not scattered randomly through phase space. Instead, they are strongly correlated and confined to a comparatively small region. The chaotic attractor lies within this same region, suggesting a direct geometric link between the organization of unstable equilibria and the collective structure of the dynamics. This picture helps explain why networks with extensive chaos can nevertheless display dynamics dominated by a relatively small number of collective modes. More broadly, the results suggest that the geometry of equilibria provides a useful complementary perspective to dynamical mean-field theory for understanding high-dimensional neural dynamics. Presented in the van Vreeswijk Theoretical Neuroscience Seminar series (formerly WWTNS) on 2026-05-27. Recording duration: 00:46:40.

Traditional work in the study of human reward-based learning involves designing an experimental task---often inspired by Reinforcement Learning (RL) theory---and fits a small set of computational models---often inspired by RL algorithms---to that dataset. For example, researchers often model human behavior on bandit tasks using variants of Q-learning. While this approach has been highly productive, leading to landmark discoveries such as the dopamine reward prediction error hypothesis, it also has limitations. This talk focuses on the lack of generalizability of such models: Even if they closely fit behavior on the original task, models derived from the one-task-one-model paradigm usually predict behavior on other tasks quite poorly. I argue that this lack of generalizability is a fundamental problem for the cognitive sciences: we intuitively expect our models to be robust to superficial task differences, such as variations in the number of choice options, reward probabilities, or the exact kind of non-stationarity. I will propose potential solutions to this problem along two dimensions: the behavioral dataset and the computational model. Regarding computational models, I will introduce work in which we moved beyond the limitations of hand-crafted one-off models by employing flexible, data-driven methods. These methods allowed us to compare classes of models instead of individual model instances, allowing us to cover the space of possible models more exhaustively, and innovate cognitive mechanisms very efficiently. For the behavioral dataset, we move from using single learning tasks to a comprehensive task space that encompasses most existing paradigms in the literature, while closing the gaps between them in a near-continuous fashion. Our results suggest that more general models in conjunction with broader datasets can pave the road toward increasingly general models of human reward-based learning and decision making, and a persistent departure from many aspects of RL theory. Presented in the van Vreeswijk Theoretical Neuroscience Seminar series (formerly WWTNS) on 2026-05-20. Recording duration: 00:51:19.

Networks of interconnected neurons display diverse patterns of activity. Relating these patterns to the structure of the network is a central goal of theoretical neuroscience. Classic neural field and rate models have been powerful tools for this purpose due to their analytical tractability. Here, we show that the recently-developed combinatorial threshold-linear network (CTLN) model is a mean-field theory for excitatory-inhibitory Hawkes networks, with clustered connectivity, in an inhibition-stabilized regime. This mapping allows us to leverage powerful analytical results for CTLN networks to predict diverse macroscopic dynamics of clustered Hawkes networks, including metastability between various macroscopic fixed points, limit cycles, and chaotic attractors. We will then examine an extension of this approach to models with nonlinear dendritic dynamics, focusing on dendritic calcium spikes.We uncover a marked point process mean-field theory for these n etworks and use this to examine how somatic vs dendritic-targeting connectivity shapes the mean-field equilibrium phase diagram. Presented in the van Vreeswijk Theoretical Neuroscience Seminar series (formerly WWTNS) on 2026-05-13. Recording duration: 00:54:14.

Neural oscillations are often proposed to support brain computation by routing information, organizing cell assemblies, or shaping coding dynamics. Yet these ideas usually assume rhythms that are strong, sustained, and regular, whereas in vivo oscillations are often weak, transient, noisy, and variable in frequency and phase. In this talk, I will argue that such “no-metronome” oscillations are not just noisy fluctuations, but coordinated complex dynamics with functional consequences. Combining analyses of neural activity recordings during actual behavior (mice and non-human-primate LFPs and human EEG) with computational modelling, I will discuss evidence that transient oscillatory events can carry task-relevant information and support flexible communication through spatiotemporally structured relationships across populations, timescales, and frequencies. Together, these results suggest that oscillatory weakness and weirdness are not just imperfections, noise to average-out, but part of the functional repertoire of neural computation Presented in the van Vreeswijk Theoretical Neuroscience Seminar series (formerly WWTNS) on 2026-05-06. Recording duration: 00:40:47.