Brain Nuclei
brain nuclei
Reflex Regulation of Innate Immunity
Reflex circuits in the nervous system integrate changes in the environment with physiology. Compact clusters of brain neuron cell bodies, termed nuclei, are essential for receiving sensory input and for transmitting motor outputs to the body. These nucelii are critical relay stations which process incoming information and convert these signals to outgoing action potentials which regulate immune system functions. Thus, reflex neural circuits maintain parameters of immunological physiology within a narrow range optimal for health. Advances in neuroscience and immunology using optogenetics, pharmacogenetics, and functional mapping offer a new understanding of the importance of neural circuitry underlying immunity, and offer direct paths to new therapies.
Unravelling the complexity of stress and reward processing: The innervation of midbrain nuclei by the nucleus incertus – Anatomical, electrophysiological and behavioural studies in rats
FENS Forum 2024