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79 curated items60 Seminars15 ePosters4 Positions
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Position

Professor Fiona Newell

Institute of Neuroscience, Trinity College Dublin
Dublin, Ireland
Dec 5, 2025

Applications are invited for the role of Post-doctoral Researcher at Trinity College Institute of Neuroscience (TCIN). The aim of the project is to elucidate the behavioural and brain processes underpinning combined visual, auditory and haptic object categorization, in children and in adults, and assess the extent to which such categories adapt to changes in task conditions. The research adopts a multidisciplinary approach involving cognitive neuroscience, statistical modelling, and psychophysics. The candidate will work within the Multisensory Cognition lab, headed by Professor Fiona Newell, and will also work in collaboration with Prof. Robert Whelan and his research team. Both groups are based in TCIN and affiliated with the School of Psychology. The Multisensory Cognition lab has dedicated laboratory facility equipped with state-of art facilities for behavioural testing, including eye tracking and VR technology (HTC Vive and Oculus). TCIN also houses a research-dedicated MRI scanner, accessible to all principal investigators and their groups. The position is funded for 2 years initially, with a possibility for continuation, and is available immediately. Ideally, successful candidates are expected to take up the position no later than March 2022. The post-doctoral researcher will join a research team of PhD students, postdoctoral researchers, and a research assistant/lab manager and have the opportunity to collaborate with colleagues within the Institute of Neuroscience, across other disciplines in Trinity College, and industrial partners. They will participate in regular lab and collaborator meetings, learn about diverse methodologies in perceptual science and have the opportunity to attend major international conferences in the field. Funding Information The position is funded by Science Foundation Ireland, from a Future Frontiers Award to Fiona Newell (Principal Investigator).

SeminarNeuroscience

Biomolecular condensates as drivers of neuroinflammation

Steven Boeynaems
Department of Molecular and Human Genetics, Baylor College of Medicine Duncan Neurological Research Institute, Texas Children's Hospital, USA
Nov 3, 2025
SeminarNeuroscience

Examining dexterous motor control in children born with a below elbow deficiency

Wilsaan Joiner
Professor, Neurobiology, Physiology & Behavior, UC Davis
Mar 9, 2025
SeminarNeuroscience

Structural & Functional Neuroplasticity in Children with Hemiplegia

Christos Papadelis
University of Texas at Arlington
Feb 20, 2025

About 30% of children with cerebral palsy have congenital hemiplegia, resulting from periventricular white matter injury, which impairs the use of one hand and disrupts bimanual co-ordination. Congenital hemiplegia has a profound effect on each child's life and, thus, is of great importance to the public health. Changes in brain organization (neuroplasticity) often occur following periventricular white matter injury. These changes vary widely depending on the timing, location, and extent of the injury, as well as the functional system involved. Currently, we have limited knowledge of neuroplasticity in children with congenital hemiplegia. As a result, we provide rehabilitation treatment to these children almost blindly based exclusively on behavioral data. In this talk, I will present recent research evidence of my team on understanding neuroplasticity in children with congenital hemiplegia by using a multimodal neuroimaging approach that combines data from structural and functional neuroimaging methods. I will further present preliminary data regarding functional improvements of upper extremities motor and sensory functions as a result of rehabilitation with a robotic system that involves active participation of the child in a video-game setup. Our research is essential for the development of novel or improved neurological rehabilitation strategies for children with congenital hemiplegia.

SeminarNeuroscience

SYNGAP1 Natural History Study/ Multidisciplinary Clinic at Children’s Hospital Colorado

Megan Abbott, MD
Children's Hospital Colorado
Jul 16, 2024
SeminarNeuroscienceRecording

Vision Unveiled: Understanding Face Perception in Children Treated for Congenital Blindness

Sharon Gilad-Gutnick
MIT
May 1, 2024
SeminarNeuroscience

Dyslexia, Rhythm, Language and the Developing Brain

Usha Goswami CBE
University of Cambridge
Feb 21, 2024

Recent insights from auditory neuroscience provide a new perspective on how the brain encodes speech. Using these recent insights, I will provide an overview of key factors underpinning individual differences in children’s development of language and phonology, providing a context for exploring atypical reading development (dyslexia). Children with dyslexia are relatively insensitive to acoustic cues related to speech rhythm patterns. This lack of rhythmic sensitivity is related to the atypical neural encoding of rhythm patterns in speech by the brain. I will describe our recent data from infants as well as children, demonstrating developmental continuity in the key neural variables.

SeminarNeuroscienceRecording

Vision Unveiled: Understanding Face Perception in Children Treated for Congenital Blindness

Sharon Gilad-Gutnick
MIT
Jun 19, 2023

Despite her still poor visual acuity and minimal visual experience, a 2-3 month old baby will reliably respond to facial expressions, smiling back at her caretaker or older sibling. But what if that same baby had been deprived of her early visual experience? Will she be able to appropriately respond to seemingly mundane interactions, such as a peer’s facial expression, if she begins seeing at the age of 10? My work is part of Project Prakash, a dual humanitarian/scientific mission to identify and treat curably blind children in India and then study how their brain learns to make sense of the visual world when their visual journey begins late in life. In my talk, I will give a brief overview of Project Prakash, and present findings from one of my primary lines of research: plasticity of face perception with late sight onset. Specifically, I will discuss a mixed methods effort to probe and explain the differential windows of plasticity that we find across different aspects of distributed face recognition, from distinguishing a face from a nonface early in the developmental trajectory, to recognizing facial expressions, identifying individuals, and even identifying one’s own caretaker. I will draw connections between our empirical findings and our recent theoretical work hypothesizing that children with late sight onset may suffer persistent face identification difficulties because of the unusual acuity progression they experience relative to typically developing infants. Finally, time permitting, I will point to potential implications of our findings in supporting newly-sighted children as they transition back into society and school, given that their needs and possibilities significantly change upon the introduction of vision into their lives.

SeminarNeuroscience

Translational Research in Tuberous Sclerosis as a Model for Autism and Epilepsy

Mustafa Sahin
Boston Children's Hospital & Harvard University
Jun 13, 2023
SeminarPsychology

Brain and Behavior: Employing Frequency Tagging as a Tool for Measuring Cognitive Abilities

Stefanie Peykarjou
University of Heidelberg
May 23, 2023

Frequency tagging based on fast periodic visual stimulation (FPVS) provides a window into ongoing visual and cognitive processing and can be leveraged to measure rule learning and high-level categorization. In this talk, I will present data demonstrating highly proficient categorization as living and non-living in preschool children, and characterize the development of this ability during infancy. In addition to associating cognitive functions with development, an intriguing question is whether frequency tagging also captures enduring individual differences, e.g. in general cognitive abilities. First studies indicate high psychometric quality of FPVS categorization responses (XU et al., Dzhelyova), providing a basis for research on individual differences. I will present results from a pilot study demonstrating high correlations between FPVS categorization responses and behavioral measures of processing speed and fluid intelligences. Drawing upon this first evidence, I will discuss the potential of frequency tagging for diagnosing cognitive functions across development.

SeminarNeuroscience

Learning through the eyes and ears of a child

Brenden Lake
NYU
Apr 20, 2023

Young children have sophisticated representations of their visual and linguistic environment. Where do these representations come from? How much knowledge arises through generic learning mechanisms applied to sensory data, and how much requires more substantive (possibly innate) inductive biases? We examine these questions by training neural networks solely on longitudinal data collected from a single child (Sullivan et al., 2020), consisting of egocentric video and audio streams. Our principal findings are as follows: 1) Based on visual only training, neural networks can acquire high-level visual features that are broadly useful across categorization and segmentation tasks. 2) Based on language only training, networks can acquire meaningful clusters of words and sentence-level syntactic sensitivity. 3) Based on paired visual and language training, networks can acquire word-referent mappings from tens of noisy examples and align their multi-modal conceptual systems. Taken together, our results show how sophisticated visual and linguistic representations can arise through data-driven learning applied to one child’s first-person experience.

SeminarNeuroscience

Expanding the role of MAST kinases in brain development and epilepsy: identification of de novo pathogenic variants in MAST4

Kimberly Aldinger
University of Washington; Seattle Children's Research Institute
Apr 18, 2023
SeminarNeuroscienceRecording

How Children Design by Analogy: The Role of Spatial Thinking

Caiwei Zhu
Delft University of Technology
Mar 15, 2023

Analogical reasoning is a common reasoning tool for learning and problem-solving. Existing research has extensively studied children’s reasoning when comparing, or choosing from ready-made analogies. Relatively less is known about how children come up with analogies in authentic learning environments. Design education provides a suitable context to investigate how children generate analogies for creative learning purposes. Meanwhile, the frequent use of visual analogies in design provides an additional opportunity to understand the role of spatial reasoning in design-by-analogy. Spatial reasoning is one of the most studied human cognitive factors and is critical to the learning of science, technology, engineering, arts, and mathematics (STEAM). There is growing interest in exploring the interplay between analogical reasoning and spatial reasoning. In this talk, I will share qualitative findings from a case study, where a class of 11-to-12-year-olds in the Netherlands participated in a biomimicry design project. These findings illustrate (1) practical ways to support children’s analogical reasoning in the ideation process and (2) the potential role of spatial reasoning as seen in children mapping form-function relationships in nature analogically and adaptively to those in human designs.

SeminarNeuroscienceRecording

Fragile minds in a scary world: trauma and post traumatic stress in very young children

Tim Dalgleish
MRC Cognition and Brain Sciences Unit, University of Cambridge
Mar 13, 2023

Post traumatic stress disorder (PTSD) is a prevalent and disabling condition that affects larger numbers of children and adolescents worldwide. Until recently, we have understood little about the nature of PTSD reactions in our youngest children (aged under 8 years old). This talk describes our work over the last 15 years working with this very young age group. It overviews how we need a markedly different PTSD diagnosis for very young children, data on the prevalence of this new diagnostic algorithm, and the development of a psychological intervention and its evaluation in a clinical trial.

SeminarNeuroscienceRecording

Cognitive supports for analogical reasoning in rational number understanding

Shuyuan Yu
Carleton University
Mar 2, 2023

In cognitive development, learning more than the input provides is a central challenge. This challenge is especially evident in learning the meaning of numbers. Integers – and the quantities they denote – are potentially infinite, as are the fractional values between every integer. Yet children’s experiences of numbers are necessarily finite. Analogy is a powerful learning mechanism for children to learn novel, abstract concepts from only limited input. However, retrieving proper analogy requires cognitive supports. In this talk, I seek to propose and examine number lines as a mathematical schema of the number system to facilitate both the development of rational number understanding and analogical reasoning. To examine these hypotheses, I will present a series of educational intervention studies with third-to-fifth graders. Results showed that a short, unsupervised intervention of spatial alignment between integers and fractions on number lines produced broad and durable gains in fractional magnitudes. Additionally, training on conceptual knowledge of fractions – that fractions denote magnitude and can be placed on number lines – facilitates explicit analogical reasoning. Together, these studies indicate that analogies can play an important role in rational number learning with the help of number lines as schemas. These studies shed light on helpful practices in STEM education curricula and instructions.

SeminarNeuroscience

SYNGAP1 and Epilepsy SurgerySYNGAP1 and Epilepsy Surgery

Taylor Abel, MD and Monika Jones, JD
Pediatric Epilepsy Surgery Program at UPMC Children’s Hospital of Pittsburgh/Pediatric Epilepsy Surgery Alliance
Feb 15, 2023
SeminarNeuroscienceRecording

Children-Agent Interaction For Assessment and Rehabilitation: From Linguistic Skills To Mental Well-being

Micole Spitale
Department of Computer Science and Technology, University of Cambridge
Feb 6, 2023

Socially Assistive Robots (SARs) have shown great potential to help children in therapeutic and healthcare contexts. SARs have been used for companionship, learning enhancement, social and communication skills rehabilitation for children with special needs (e.g., autism), and mood improvement. Robots can be used as novel tools to assess and rehabilitate children’s communication skills and mental well-being by providing affordable and accessible therapeutic and mental health services. In this talk, I will present the various studies I have conducted during my PhD and at the Cambridge Affective Intelligence and Robotics Lab to explore how robots can help assess and rehabilitate children’s communication skills and mental well-being. More specifically, I will provide both quantitative and qualitative results and findings from (i) an exploratory study with children with autism and global developmental disorders to investigate the use of intelligent personal assistants in therapy; (ii) an empirical study involving children with and without language disorders interacting with a physical robot, a virtual agent, and a human counterpart to assess their linguistic skills; (iii) an 8-week longitudinal study involving children with autism and language disorders who interacted either with a physical or a virtual robot to rehabilitate their linguistic skills; and (iv) an empirical study to aid the assessment of mental well-being in children. These findings can inform and help the child-robot interaction community design and develop new adaptive robots to help assess and rehabilitate linguistic skills and mental well-being in children.

SeminarNeuroscienceRecording

Applying Structural Alignment theory to Early Verb Learning

Jane Childers
Trinity University
Feb 2, 2023

Learning verbs is difficult and critical to learning one's native language. Children appear to benefit from seeing multiple events and comparing them to each other, and structural alignment theory provides a good theoretical framework to guide research into how preschool children may be comparing events as they learn new verbs. The talk will include 6 studies of early verb learning that make use of eye-tracking procedures as well as other behavioral (pointing) procedures, and that test key predictions from SA theory including the prediction that seeing similar examples before more varied examples helps observers learn how to compare (progressive alignment) and the prediction that when events have very low alignability with other events, that is one cue that the events should be ignored. Whether or how statistical learning may also be at work will be considered.

SeminarNeuroscienceRecording

Do large language models solve verbal analogies like children do?

Claire Stevenson
University of Amsterdam
Nov 16, 2022

Analogical reasoning –learning about new things by relating it to previous knowledge– lies at the heart of human intelligence and creativity and forms the core of educational practice. Children start creating and using analogies early on, making incredible progress moving from associative processes to successful analogical reasoning. For example, if we ask a four-year-old “Horse belongs to stable like chicken belongs to …?” they may use association and reply “egg”, whereas older children will likely give the intended relational response “chicken coop” (or other term to refer to a chicken’s home). Interestingly, despite state-of-the-art AI-language models having superhuman encyclopedic knowledge and superior memory and computational power, our pilot studies show that these large language models often make mistakes providing associative rather than relational responses to verbal analogies. For example, when we asked four- to eight-year-olds to solve the analogy “body is to feet as tree is to …?” they responded “roots” without hesitation, but large language models tend to provide more associative responses such as “leaves”. In this study we examine the similarities and differences between children's and six large language models' (Dutch/multilingual models: RobBERT, BERT-je, M-BERT, GPT-2, M-GPT, Word2Vec and Fasttext) responses to verbal analogies extracted from an online adaptive learning environment, where >14,000 7-12 year-olds from the Netherlands solved 20 or more items from a database of 900 Dutch language verbal analogies.

SeminarNeuroscienceRecording

Learning by Analogy in Mathematics

Pooja Sidney
University of Kentucky
Nov 9, 2022

Analogies between old and new concepts are common during classroom instruction. While previous studies of transfer focus on how features of initial learning guide later transfer to new problem solving, less is known about how to best support analogical transfer from previous learning while children are engaged in new learning episodes. Such research may have important implications for teaching and learning in mathematics, which often includes analogies between old and new information. Some existing research promotes supporting learners' explicit connections across old and new information within an analogy. In this talk, I will present evidence that instructors can invite implicit analogical reasoning through warm-up activities designed to activate relevant prior knowledge. Warm-up activities "close the transfer space" between old and new learning without additional direct instruction.

SeminarNeuroscience

Development of Interictal Networks: Implications for Epilepsy Progression and Cognition

Jennifer Gelinas
Columbia University Medical Center, NY
Nov 1, 2022

Epilepsy is a common and disabling neurologic condition affecting adults and children that results from complex dysfunction of neural networks and is ineffectively treated with current therapies in up to one third of patients. This dysfunction can have especially severe consequences in pediatric age group, where neurodevelopment may be irreversibly affected. Furthermore, although seizures are the most obvious manifestation of epilepsy, the cognitive and psychiatric dysfunction that often coexists in patients with this disorder has the potential to be equally disabling.  Given these challenges, her research program aims to better understand how epileptic activity disrupts the proper development and function of neural networks, with the overall goal of identifying novel biomarkers and systems level treatments for epileptic disorders and their comorbidities, especially those affecting children.

SeminarNeuroscience

Baby steps to breakthroughs in precision health in neurodevelopmental disorders

Shafali Spurling Jeste
Children's Hospital Los Angeles
Oct 25, 2022
SeminarNeuroscience

Learning-to-read and dyslexia: a cross-language computational perspective

Johannes Ziegler
Aix-Marseille University & CNRS
Sep 26, 2022

How do children learn to read in different countries? How do deficits in various components of the reading network affect learning outcomes? What are the consequences of such deficits in different languages? In this talk, I will present a full-blown developmentally plausible computational model of reading acquisition that has been implemented in English, French, Italian and German. The model can simulate individual learning trajectories and intervention outcomes on the basis of three component skills: orthography, phonology, and vocabulary. I will use the model to show how cross-language differences affect the learning-to-read process in different languages and to investigate to what extent similar deficits will produce similar or different manifestations of dyslexia in different languages.

SeminarNeuroscienceRecording

Analogy Use in Parental Explanation

Yang Gao
Tsinghua University
Jul 7, 2022

How and why are analogies spontaneously generated? Despite the prominence of analogy in learning and reasoning, there is little research on whether and how analogy is spontaneously generated in everyday settings. Here we fill this gap by gathering parents' answers to children's real questions, and examining analogy use in parental explanations. Study 1 found that parents used analogy spontaneously in their explanations, despite no prompt nor mention of analogy in the instruction. Study 2 found that these analogical explanations were rated highly by parents, schoolteachers, and university students alike. In Study 3, six-year-olds also rated good analogical explanations highly, but unlike their parents, did not rate them higher than causal, non-analogical explanations. We discuss what makes an analogy a good explanation, and how theories from both explanation and analogy research explain one’s motivation for spontaneously generating analogies.

SeminarNeuroscienceRecording

How Children Discover Mathematical Structure through Relational Mapping

Kelly Mix
University of Maryland
Jun 29, 2022

A core question in human development is how we bring meaning to conventional symbols. This question is deeply connected to understanding how children learn mathematics—a symbol system with unique vocabularies, syntaxes, and written forms. In this talk, I will present findings from a program of research focused on children’s acquisition of place value symbols (i.e., multidigit number meanings). The base-10 symbol system presents a variety of obstacles to children, particularly in English. Children who cannot overcome these obstacles face years of struggle as they progress through the mathematics curriculum of the upper elementary and middle school grades. Through a combination of longitudinal, cross-sectional, and pretest-training-posttest approaches, I aim to illuminate relational learning mechanisms by which children sometimes succeed in mastering the place value system, as well as instructional techniques we might use to help those who do not.

SeminarNeuroscience

Learning from others, helping others learn: Cognitive foundations of distinctively human social learning

Hyowon (Hyo) Gweon
Stanford University
May 31, 2022

Learning does not occur in isolation. From parent-child interactions to formal classroom environments, humans explore, learn, and communicate in rich, diverse social contexts. Rather than simply observing and copying their conspecifics, humans engage in a range of epistemic practices that actively recruit those around them. What makes human social learning so distinctive, powerful, and smart? In this talk, I will present a series of studies that reveal the remarkably sophisticated inferential abilities that young children show not only in how they learn from others but also in how they help others learn. Children interact with others as learners and as teachers to learn and communicate about the world, about others, and even about the self. The results collectively paint a picture of human social learning that is far more than copying and imitation: It is active, bidirectional, and cooperative. I will end by discussing ongoing work that extends this picture beyond what we typically call “social learning”, with implications for building better machines that learn from and interact with humans.

SeminarNeuroscienceRecording

Children’s inference of verb meanings: Inductive, analogical and abductive inference

Mutsumi Imai
Keio University
May 18, 2022

Children need inference in order to learn the meanings of words. They must infer the referent from the situation in which a target word is said. Furthermore, to be able to use the word in other situations, they also need to infer what other referents the word can be generalized to. As verbs refer to relations between arguments, verb learning requires relational analogical inference, something which is challenging to young children. To overcome this difficulty, young children recruit a diverse range of cues in their inference of verb meanings, including, but not limited to, syntactic cues and social and pragmatic cues as well as statistical cues. They also utilize perceptual similarity (object similarity) in progressive alignment to extract relational verb meanings and further to gain insights about relational verb meanings. However, just having a list of these cues is not useful: the cues must be selected, combined, and coordinated to produce the optimal interpretation in a particular context. This process involves abductive reasoning, similar to what scientists do to form hypotheses from a range of facts or evidence. In this talk, I discuss how children use a chain of inferences to learn meanings of verbs. I consider not only the process of analogical mapping and progressive alignment, but also how children use abductive inference to find the source of analogy and gain insights into the general principles underlying verb learning. I also present recent findings from my laboratory that show that prelinguistic human infants use a rudimentary form of abductive reasoning, which enables the first step of word learning.

SeminarNeuroscience

Mapping Individual Trajectories of Structural and Cognitive Decline in Mild Cognitive Impairment

Shreya Rajagopal
Psychology, University of Michigan
Mar 24, 2022

The US has an aging population. For the first time in US history, the number of older adults is projected to outnumber that of children by 2034. This combined with the fact that the prevalence of Alzheimer's Disease increases exponentially with age makes for a worrying combination. Mild cognitive impairment (MCI) is an intermediate stage of cognitive decline between being cognitively normal and having full-blown Dementia, with every third person with MCI progressing to dementia of the Alzheimer's Type (DAT). While there is no known way to reverse symptoms once they begin, early prediction of disease can help stall its progression and help with early financial planning. While grey matter volume loss in the Hippocampus and Entorhinal Cortex (EC) are characteristic biomarkers of DAT, little is known about the rates of decrease of these volumes within individuals in MCI state across time. We used longitudinal growth curve models to map individual trajectories of volume loss in subjects with MCI. We then looked at whether these rates of volume decrease could predict progression to DAT right in the MCI stage. Finally, we evaluated whether these rates of Hippocampal and EC volume loss were correlated with individual rates of decline of episodic memory, visuospatial ability, and executive function.

SeminarNeuroscienceRecording

Assessing the potential for learning analogy problem-solving: does EF play a role?

Bart Vogelaar
Leiden University
Mar 23, 2022

Analogical reasoning is related to everyday learning and scholastic learning and is a robust predictor of g. Therefore, children's ability to reason by analogy is often measured in a school context to gain insight into children's cognitive and intellectual functioning. Often, the ability to reason by analogy is measured by means of conventional, static instruments. Static tests are criticised by researchers and practitioners to provide an overview of what individuals have learned in the past and for this reason are assumed not to tap into the potential for learning, based on Vygotsky's zone of proximal development. This seminar will focus on children's potential for reasoning by analogy, as measured by means of a dynamic test, which has a test-training-test design. In so doing, the potential relationship between dynamic test outcomes and executive functioning will be explored.

SeminarNeuroscienceRecording

Mechanisms of visual circuit development: aligning topographic maps of space

Jason Triplett
Department of Pharmacology & Physiology & Pediatrics, The George Washington University - Center for Neurosciences Research, The Children’s National.
Mar 21, 2022
SeminarNeuroscienceRecording

Do Capuchin Monkeys, Chimpanzees and Children form Overhypotheses from Minimal Input? A Hierarchical Bayesian Modelling Approach

Elisa Felsche
Max Planck Institute for Evolutionary Anthropology
Mar 9, 2022

Abstract concepts are a powerful tool to store information efficiently and to make wide-ranging predictions in new situations based on sparse data. Whereas looking-time studies point towards an early emergence of this ability in human infancy, other paradigms like the relational match to sample task often show a failure to detect abstract concepts like same and different until the late preschool years. Similarly, non-human animals have difficulties solving those tasks and often succeed only after long training regimes. Given the huge influence of small task modifications, there is an ongoing debate about the conclusiveness of these findings for the development and phylogenetic distribution of abstract reasoning abilities. Here, we applied the concept of “overhypotheses” which is well known in the infant and cognitive modeling literature to study the capabilities of 3 to 5-year-old children, chimpanzees, and capuchin monkeys in a unified and more ecologically valid task design. In a series of studies, participants themselves sampled reward items from multiple containers or witnessed the sampling process. Only when they detected the abstract pattern governing the reward distributions within and across containers, they could optimally guide their behavior and maximize the reward outcome in a novel test situation. We compared each species’ performance to the predictions of a probabilistic hierarchical Bayesian model capable of forming overhypotheses at a first and second level of abstraction and adapted to their species-specific reward preferences.

SeminarNeuroscience

Mapping microglia states and function in health and disease

Beth Stevens
Boston Children's Hospital, Harvard University, Boston, USA
Feb 1, 2022
SeminarNeuroscienceRecording

How bilingualism modulates the neural mechanisms of selective attention

Mirjana Bozic
Department of Psychology, University of Cambridge
Jan 31, 2022

Learning and using multiple languages places considerable demands on our cognitive system, and has been shown to modulate the mechanisms of selective attention in both children and adults. Yet the nature of these adaptive changes is still not entirely clear. One possibility is that bilingualism boosts the capacity for selective attention; another is that it leads to a different distribution of this finite resource, aimed at supporting optimal performance under the increased processing demands. I will present a series of studies investigating the nature of modifications of selective attention in bilingualism. Using behavioural and neuroimaging techniques, our data confirm that bilingualism modifies the neural mechanisms of selective attention even in the absence of behavioural differences between monolinguals and bilinguals. They further suggest that, instead of enhanced attentional capacity, these neuroadaptive modifications appear to reflect its redistribution, arguably aimed at economising the available resources to support optimal behavioural performance.

SeminarNeuroscience

JAK/STAT regulation of the transcriptomic response during epileptogenesis

Amy Brooks-Kayal
Children's Hospital Colorado / UC Davis
Dec 14, 2021

Temporal lobe epilepsy (TLE) is a progressive disorder mediated by pathological changes in molecular cascades and neural circuit remodeling in the hippocampus resulting in increased susceptibility to spontaneous seizures and cognitive dysfunction. Targeting these cascades could prevent or reverse symptom progression and has the potential to provide viable disease-modifying treatments that could reduce the portion of TLE patients (>30%) not responsive to current medical therapies. Changes in GABA(A) receptor subunit expression have been implicated in the pathogenesis of TLE, and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway has been shown to be a key regulator of these changes. The JAK/STAT pathway is known to be involved in inflammation and immunity, and to be critical for neuronal functions such as synaptic plasticity and synaptogenesis. Our laboratories have shown that a STAT3 inhibitor, WP1066, could greatly reduce the number of spontaneous recurrent seizures (SRS) in an animal model of pilocarpine-induced status epilepticus (SE). This suggests promise for JAK/STAT inhibitors as disease-modifying therapies, however, the potential adverse effects of systemic or global CNS pathway inhibition limits their use. Development of more targeted therapeutics will require a detailed understanding of JAK/STAT-induced epileptogenic responses in different cell types. To this end, we have developed a new transgenic line where dimer-dependent STAT3 signaling is functionally knocked out (fKO) by tamoxifen-induced Cre expression specifically in forebrain excitatory neurons (eNs) via the Calcium/Calmodulin Dependent Protein Kinase II alpha (CamK2a) promoter. Most recently, we have demonstrated that STAT3 KO in excitatory neurons (eNSTAT3fKO) markedly reduces the progression of epilepsy (SRS frequency) in the intrahippocampal kainate (IHKA) TLE model and protects mice from kainic acid (KA)-induced memory deficits as assessed by Contextual Fear Conditioning. Using data from bulk hippocampal tissue RNA-sequencing, we further discovered a transcriptomic signature for the IHKA model that contains a substantial number of genes, particularly in synaptic plasticity and inflammatory gene networks, that are down-regulated after KA-induced SE in wild-type but not eNSTAT3fKO mice. Finally, we will review data from other models of brain injury that lead to epilepsy, such as TBI, that implicate activation of the JAK/STAT pathway that may contribute to epilepsy development.

SeminarNeuroscience

A transdiagnostic data-driven study of children’s behaviour and the functional connectome

Jonathan Jones
Universiy of Cambridge, MRC CBU
Nov 23, 2021

Behavioural difficulties are seen as hallmarks of many neurodevelopmental conditions. Differences in functional brain organisation have been observed in these conditions, but little is known about how they are related to a child’s profile of behavioural difficulties. We investigated whether behavioural difficulties are associated with how the brain is functionally organised in an intentionally heterogeneous and transdiagnostic sample of 957 children aged 5-15. We used consensus community detection to derive data-driven profiles of behavioural difficulties and constructed functional connectomes from a subset of 238 children with resting-state functional Magnetic Resonance Imaging (fMRI) data. We identified three distinct profiles of behaviour that were characterised by principal difficulties with hot executive function, cool executive function, and learning. Global organisation of the functional connectome did not differ between the groups, but multivariate patterns of connectivity at the level of Intrinsic Connectivity Networks (ICNs), nodes, and hubs significantly predicted group membership in held-out data. Fronto-parietal connector hubs were under-connected in all groups relative to a comparison sample, and children with hot vs cool executive function difficulties were distinguished by connectivity in ICNs associated with cognitive control, emotion processing, and social cognition. This demonstrates both general and specific neurodevelopmental risk factors in the functional connectome. (https://www.medrxiv.org/content/10.1101/2021.09.15.21262637v1)

SeminarNeuroscienceRecording

Retinoblastoma: Canadian global leadership

Brenda Gallie
Hospital for Sick Children, Alberta Children’s Hospital, Techna Institute and Krembil Research Institute, University Health Network, Departments Ophthalmology, Medical Biophysics, Molecular Genetics, University of Toronto.
Nov 15, 2021
SeminarNeuroscienceRecording

Transdiagnostic approaches to understanding neurodevelopment

Duncan Astle
MRC Cognition and Brain Sciences Unit, University of Cambridge
Nov 8, 2021

Macroscopic brain organisation emerges early in life, even prenatally, and continues to develop through adolescence and into early adulthood. The emergence and continual refinement of large-scale brain networks, connecting neuronal populations across anatomical distance, allows for increasing functional integration and specialisation. This process is thought crucial for the emergence of complex cognitive processes. But how and why is this process so diverse? We used structural neuroimaging collected from a large diverse cohort, to explore how different features of macroscopic brain organisation are associated with diverse cognitive trajectories. We used diffusion-weighted imaging (DWI) to construct whole-brain white-matter connectomes. A simulated attack on each child's connectome revealed that some brain networks were strongly organized around highly connected 'hubs'. The more children's brains were critically dependent on hubs, the better their cognitive skills. Conversely, having poorly integrated hubs was a very strong risk factor for cognitive and learning difficulties across the sample. We subsequently developed a computational framework, using generative network modelling (GNM), to model the emergence of this kind of connectome organisation. Relatively subtle changes within the wiring rules of this computational framework give rise to differential developmental trajectories, because of small biases in the preferential wiring properties of different nodes within the network. Finally, we were able to use this GNM to implicate the molecular and cellular processes that govern these different growth patterns.

SeminarNeuroscienceRecording

Pelizaeus-Merzbacher disease and related disorders

Nicole Wolf
Emma Children’s Hospital, Amsterdam University Medical Centre, the Netherlands
Oct 25, 2021
SeminarNeuroscienceRecording

Children's relational noun generalization strategies

Eleanor Stansbury
Université de Bourgogne
Oct 13, 2021

A common result is that comparison settings (i.e., several stimuli introduced simultaneously) favor conceptualization and generalization. However still little is known of the solving strategies used by children to compare and generalize novel words. Understanding the temporal dynamics of children’s solving strategies may help assess which processes underlie generalization. We tested children in noun and relational noun generalization tasks and collected eye tracking data. To analyze and interpret the data we followed predictions made by existing models of analogical reasoning and generalization. The data reveals clear patterns of exploration in which participants compare learning items before searching for a solution. Analyses of the beginning of trials show that early comparisons favor generalization and that errors may be caused by a lake of early comparison. Children then pursue their search in different ways according to the task. In this presentation I will present the generalization strategies revealed by eye tracking, compare the strategies from both tasks and confront them to existing models.

SeminarNeuroscienceRecording

Pediatric Migraine: Who, What, When, Where

Amy Gelfand
UCSF Benioff Children's Hospitals, USA
Sep 29, 2021

This talk will address important aspects of pediatric migraine research, including: 1) Who is affected by pediatric migraine? 2) What does pediatric migraine look like, and what does a clinician need to do to reach a migraine diagnosis in a child? 3) When does pediatric migraine begin, and how might it present clinically before it presents as headache (e.g., infant colic, benign paroxysmal torticollis, cyclic vomiting syndrome etc.) 4) Where does responsibility for decreasing pediatric migraine frequency rest? What is society's role in preventing migraine in young people?

SeminarNeuroscience

Overdrawn at the ion bank: brain injury, neuronal chloride levels, and seizures

Kevin Staley
MassGeneral Hospital for Children
Sep 7, 2021
SeminarNeuroscienceRecording

Achieving Abstraction: Early Competence & the Role of the Learning Context

Caren Walker
University of California, San Diego
Jul 14, 2021

Children's emerging ability to acquire and apply relational same-different concepts is often cited as a defining feature of human cognition, providing the foundation for abstract thought. Yet, young learners often struggle to ignore irrelevant surface features to attend to structural similarity instead. I will argue that young children have--and retain--genuine relational concepts from a young age, but tend to neglect abstract similarity due to a learned bias to attend to objects and their properties. Critically, this account predicts that differences in the structure of children's environmental input should lead to differences in the type of hypotheses they privilege and apply. I will review empirical support for this proposal that has (1) evaluated the robustness of early competence in relational reasoning, (2) identified cross-cultural differences in relational and object bias, and (3) provided evidence that contextual factors play a causal role in relational reasoning. Together, these studies suggest that the development of abstract thought may be more malleable and context-sensitive than initially believed.

SeminarNeuroscience

Making memories in mice

Sheena Josselyn
The Hospital for Sick Children
Jun 30, 2021

Understanding how the brain uses information is a fundamental goal of neuroscience. Several human disorders (ranging from autism spectrum disorder to PTSD to Alzheimer’s disease) may stem from disrupted information processing. Therefore, this basic knowledge is not only critical for understanding normal brain function, but also vital for the development of new treatment strategies for these disorders. Memory may be defined as the retention over time of internal representations gained through experience, and the capacity to reconstruct these representations at later times. Long-lasting physical brain changes (‘engrams’) are thought to encode these internal representations. The concept of a physical memory trace likely originated in ancient Greece, although it wasn’t until 1904 that Richard Semon first coined the term ‘engram’. Despite its long history, finding a specific engram has been challenging, likely because an engram is encoded at multiple levels (epigenetic, synaptic, cell assembly). My lab is interested in understanding how specific neurons are recruited or allocated to an engram, and how neuronal membership in an engram may change over time or with new experience. Here I will describe both older and new unpublished data in our efforts to understand memories in mice.

SeminarNeuroscience

Neuro-Immune Coupling: How the Immune System Sculpts Brain Circuitry

Beth Stevens
Boston Children's Hospital/Harvard Medical School, Boston, MA, USA
Jun 20, 2021

In this lecture, Dr Stevens will discuss recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to autism, schizophrenia and other brain disorders. Her recent work revealed a key role for microglia and a group of immune related molecules called complement in normal developmental synaptic pruning, a normal process required to establish precise brain wiring. Emerging evidence suggests aberrant regulation of this pruning pathway may contribute to synaptic and cognitive dysfunction in a host of brain disorders, including schizophrenia. Recent research has revealed that a person’s risk of schizophrenia is increased if they inherit specific variants in complement C4, gene plays a well-known role in the immune system but also helps sculpt developing synapses in the mouse visual system (Sekar et al., 2016). Together these findings may help explain known features of schizophrenia, including reduced numbers of synapses in key cortical regions and an adolescent age of onset that corresponds with developmentally timed waves of synaptic pruning in these regions. Stevens will discuss this and ongoing work to understand the mechanisms by which complement and microglia prune specific synapses in the brain. A deeper understanding of how these immune mechanisms mediate synaptic pruning may provide novel insight into how to protect synapses in autism and other brain disorders, including Alzheimer’s and Huntington’s Disease.

SeminarNeuroscience

Generative models of the human connectome

Prof Alex Fornito and Dr Stuart Oldham
Jun 9, 2021

The human brain is a complex network of neuronal connections. The precise arrangement of these connections, otherwise known as the topology of the network, is crucial to its functioning. Recent efforts to understand how the complex topology of the brain has emerged have used generative mathematical models, which grow synthetic networks according to specific wiring rules. Evidence suggests that a wiring rule which emulates a trade-off between connection costs and functional benefits can produce networks that capture essential topological properties of brain networks. In this webinar, Professor Alex Fornito and Dr Stuart Oldham will discuss these previous findings, as well as their own efforts in creating more physiologically constrained generative models. Professor Alex Fornito is Head of the Brain Mapping and Modelling Research Program at the Turner Institute for Brain and Mental Health. His research focuses on developing new imaging techniques for mapping human brain connectivity and applying these methods to shed light on brain function in health and disease. Dr Stuart Oldham is a Research Fellow at the Turner Institute for Brain and Mental Health and a Research Officer at the Murdoch Children’s Research Institute. He is interested in characterising the organisation of human brain networks, with particular focus on how this organisation develops, using neuroimaging and computational tools.

SeminarNeuroscienceRecording

MRI pattern recognition in leukodystrophies

Nicole Wolf
Emma Children’s Hospital, Amsterdam University Medical Centre, the Netherlands
Jun 7, 2021
SeminarNeuroscience

Models of Core Knowledge (Physics, Really)

Tomer Ullman
Harvard University
Jun 1, 2021

Even young children seem to have an early understanding of the world around them, and the people in it. Before children can reliably say "ball", "wall", or "Saul", they expect balls to not go through walls, and for Saul to go right for a ball (if there's no wall). What is the formal conceptual structure underlying this commonsense reasoning about objects and agents? I will raise several possibilities for models underlying core intuitive physics as a way of talking about models of core knowledge and intuitive theories more generally. In particular, I will present some recent ML work trying to capture early expectations about object solidly, cohesion, and permanence, that relies on a rough-derendering approach.

SeminarNeuroscienceRecording

Unpacking Nature from Nurture: Understanding how Family Processes Affect Child and Adolescent Mental Health

Gordon Harold
Faculty of Education, University of Cambridge
Apr 26, 2021

Mental Health problems among youth constitutes an area of significant social, educational, clinical, policy and public health concern. Understanding processes and mechanisms that underlie the development of mental health problems during childhood and adolescence requires theoretical and methodological integration across multiple scientific domains, including developmental science, neuroscience, genetics, education and prevention science. The primary focus of this presentation is to examine the relative role of genetic and family environmental influences on children’s emotional and behavioural development. Specifically, a complementary array of genetically sensitive and longitudinal research designs will be employed to examine the role of early environmental adversity (e.g. inter-parental conflict, negative parenting practices) relative to inherited factors in accounting for individual differences in children’s symptoms of psychopathology (e.g. depression, aggression, ADHD ). Examples of recent applications of this research to the development of evidence-based intervention programmes aimed at reducing psychopathology in the context of high-risk family settings will also be presented.

SeminarNeuroscience

Sensory Processing and Arousal in Neurodevelopmental Disorders

Michela Fagiolini
Boston Children's Hospital
Apr 13, 2021
SeminarNeuroscienceRecording

Structure-mapping in Human Learning

Dedre Gentner
Northwestern University
Apr 1, 2021

Across species, humans are uniquely able to acquire deep relational systems of the kind needed for mathematics, science, and human language. Analogical comparison processes are a major contributor to this ability. Analogical comparison engages a structure-mapping process (Gentner, 1983) that fosters learning in at least three ways: first, it highlights common relational systems and thereby promotes abstraction; second, it promotes inferences from known situations to less familiar situations; and, third, it reveals potentially important differences between examples. In short, structure-mapping is a domain-general learning process by which abstract, portable knowledge can arise from experience. It is operative from early infancy on, and is critical to the rapid learning we see in human children. Although structure-mapping processes are present pre-linguistically, their scope is greatly amplified by language. Analogical processes are instrumental in learning relational language, and the reverse is also true: relational language acts to preserve relational abstractions and render them accessible for future learning and reasoning. Although structure-mapping processes are present pre-linguistically, their scope is greatly amplified by language. Analogical processes are instrumental in learning relational language, and the reverse is also true: relational language acts to preserve relational abstractions and render them accessible for future learning and reasoning.

SeminarNeuroscience

The role of orexin/hypocretin in social behaviour

Derya Sargin
The Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute University of Calgary
Mar 7, 2021

My lab is focused on how brain encodes and modulates social interactions. Intraspecific social interactions are integral for survival and maintenance of society among all mammalian species. Despite the importance of social interactions, we lack a complete understanding of the brain circuitry involved in processing social behaviour. My lab investigates how the hypothalamic orexin (hypocretin) neurons and their downstream circuits participate in social interaction behaviours. These neurons are located exclusively in the hypothalamus that regulates complex and goal-directed behaviours. We recently identified that orexin neurons differentially encode interaction between familiar and novel animals. We are currently investigating how chronic social isolation, a risk factor for the development of social-anxiety like behaviours, affects orexin neuron activity and how we can manipulate the activity of these neurons to mitigate isolation-induced social deficits.

SeminarNeuroscience

Cellular/circuit dysfunction across development in a model of Dravet syndrome

Ethan Goldberg
Children's Hospital of Philadelphia
Mar 2, 2021

Dravet syndrome (DS) is a neurodevelopmental disorder caused by heterozygous loss-of-function of the gene SCN1A encoding the voltage-gated sodium channel subunit Nav1.1, and is defined by treatment-resistant epilepsy, intellectual impairment, and sudden death. However, disease mechanisms remain unclear, as previously-identified deficiency in action potential generation of Nav1.1-expressing parvalbumin-positive fast-spiking GABAergic interneurons (PV-INs) in DS (Scn1a+/-) mice normalizes during development. We used a novel approach that facilitated the assessment of PV-IN function at both early (post-natal day (P) 16-21) and late (P35-56) time points in the same mice. We confirmed that PV-IN spike generation was impaired at P16-21 in all mice (those deceased from SUDEP by P35 and those surviving to P35-56). However, unitary synaptic transmission assessed in PV-IN:principal cell paired recordings was severely dysfunctional selectively in mice recorded at P16-21 that did not survive to P35. Spike generation in surviving mice had normalized by P35-56; yet we again identified abnormalities in synaptic transmission in surviving mice. We propose that early dysfunction of PV-IN spike propagation drives epilepsy severity and risk of sudden death, while persistent dysfunction of spike propagation contributes to chronic DS pathology.

ePoster

Acute bouts of exercise in preschool children do not affect working memory capacity but accelerate the execution of the task

Ivan Serbetar, Martina Bosak, Ivana Antolić

FENS Forum 2024

ePoster

Corticocerebellar tracts and their relationship to anticipatory control deficits in children with cerebral palsy: A diffusion neuroimaging study

Ophelie Martinie, Philippe Karan, Maxime Descoteaux, Catherine Mercier, Maxime, T. Robert

FENS Forum 2024

ePoster

Effects of parenting behaviors on children’s and young adults' emotion regulatory brain structure

Mirjam Habegger, Elena Federici, Plamina Dimanova, Réka Borbás, Denis Ribeaud, Manuel Eisner, Todd Hare, Nora Maria Raschle

FENS Forum 2024

ePoster

Evolving perspectives: Children's functional brain correlates and emerging connectivity patterns during mentalizing

Réka Borbás, Dennis Saikkonen, Plamina Dimanova, Elena Federici, Sofia Scatolin, Nora M. Raschle

FENS Forum 2024

ePoster

Exposure to maternal pre- and postnatal psychological distress: Effects on brain structure in 5-year-old children

Elmo Pulli, Amira Svensk, Venla Kumpulainen, Eero Silver, Anni Copeland, Ekaterina Saukko, Harri Merisaari, Linnea Karlsson, Hasse Karlsson, Jetro Tuulari

FENS Forum 2024

ePoster

Home tobacco smoke exposure and family resilience scores among U.S. children

Ashley Merianos, Laura Nabors, Kayleigh Gregory, Madelyn Hill, E. Melinda Mahabee-Gittens

FENS Forum 2024

ePoster

The inside-out of emotion processing: Evaluating children and adults’ neural correlates from a novel fMRI movie-watching paradigm

Sofia Scatolin, Elena Federici, Plamina Dimanova, Réka Borbás, Mirjam Habegger, Nora Maria Raschle

FENS Forum 2024

ePoster

Insights into semantic language development in children with and without autism using neurophysiological and neuroimaging methods

Kathryn Toffolo, Edward Freedman, John Foxe

FENS Forum 2024

ePoster

Mapping cerebellar motor and cognitive deficits after tumor resection in children

Marina Veyrie, Carmin Mottolese, Alexandru Szathmari, Federico Di Rocco, Cécile Faure Conter, Pierre Leblond, Michel Desmurget, Irene Cristofori, Pierre-Aurélien Beuriat

FENS Forum 2024

ePoster

Neurophysiology of perceptual closure abilities in children with autism spectrum disorder and neurotypical control children

Erin Bojanek, Edward G. Freedman, John J. Foxe

FENS Forum 2024

ePoster

Plasma neurofilament light chain in Chinese children with later-onset SMA under treatment with nusinersen

Shanshan Mao, Jianing Jin

FENS Forum 2024

ePoster

Practice-related changes in prefrontal activation and representations during task switching in children

Sina Schwarze, Silvia Bunge, Ulman Lindenberger, Yana Fandakova

FENS Forum 2024

ePoster

The predictive power of neurological factors for differentiated attention functions in children and adolescents with the genetic disorder neurofibromatosis type 1

Rita Hansl, David Steyrl, Lena Fichtinger, Amedeo Azizi, Ulrike Leiss, Thomas Pletschko

FENS Forum 2024

ePoster

Structural brain reorganization in children with obstetric brachial plexus palsy

Dzerassa Kadieva, Maxim Ulanov, Anna Shestakova, Olga Agranovich, Federico Gallo

FENS Forum 2024

ePoster

Test-retest reliability analysis of EEG power measures and their association with L2 vocabulary learning in children and adults

Anastasios Ziogas, Nicole H. Skieresz, Sandy C. Marca, Simon Ruch, Nicolas Rothen, Thomas P. Reber

FENS Forum 2024