Nicotine
nicotine
Inter-individual variability in reward seeking and decision making: role of social life and consequence for vulnerability to nicotine
Inter-individual variability refers to differences in the expression of behaviors between members of a population. For instance, some individuals take greater risks, are more attracted to immediate gains or are more susceptible to drugs of abuse than others. To probe the neural bases of inter-individual variability we study reward seeking and decision-making in mice, and dissect the specific role of dopamine in the modulation of these behaviors. Using a spatial version of the multi-armed bandit task, in which mice are faced with consecutive binary choices, we could link modifications of midbrain dopamine cell dynamics with modulation of exploratory behaviors, a major component of individual characteristics in mice. By analyzing mouse behaviors in semi-naturalistic environments, we then explored the role of social relationships in the shaping of dopamine activity and associated beahviors. I will present recent data from the laboratory suggesting that changes in the activity of dopaminergic networks link social influences with variations in the expression of non-social behaviors: by acting on the dopamine system, the social context may indeed affect the capacity of individuals to make decisions, as well as their vulnerability to drugs of abuse, in particular nicotine.
Neuroimmune and Glutamatergic Mechanisms of Nicotine Addiction
Exploring the neuroprotective effects of nicotine against MPTP-induced neuronal damage in mice: Insights into antioxidant system
FENS Forum 2024
Lavandula angustifolia or astrocytes alleviate nicotine plus high glucose-induced intracellular Ca2+ elevation in neurons and microglia
FENS Forum 2024
Nicotine biases motivational valence by altering brainstem cholinergic signals
FENS Forum 2024
Nicotine exposure during adolescence disrupts the dopaminergic circuitry in the ventral tegmental area
FENS Forum 2024
Nicotine suppresses feeding behavior by exerting opposite effects on the neuronal activity of the arcuate nucleus
FENS Forum 2024
Precise spatiotemporal photorelease of a systemically administered caged nicotine agonist in freely moving mice
FENS Forum 2024
Prenatal hypoxia, maternal stress, and the impact on CHRNA7 gene expression: Linking to nicotine addiction in adult offspring
FENS Forum 2024
Role of the interneurons in prefrontal-based attentional dysfunctions in nicotine addiction
FENS Forum 2024
Understanding the influence of the gut microbiome on the mesolimbic system and its response to nicotine
FENS Forum 2024
Understanding the neurobiological basis of the rewarding properties of flavored nicotine in e-cigarettes
FENS Forum 2024