Postdoctoral scientist positions are available at the Nathan Kline Institute (NKI) for Psychiatric Research to work on computational neuroscience research funded by recently awarded NIH and DoD grants. Our NIH-funded projects investigate the brain's dynamic circuit motifs underlying internal vs. external-oriented processes in the auditory and interconnected areas, using circuit modeling of the thalamocortical system. In this project, the postdoc will build data-driven biophysical models constrained by data collected from electrophysiology labs at NKI and Columbia & The Feinstein Institutes for Medical Research, and then use the models to predict optimal neuromodulation strategies for inducing/suppressing circuit patterns, testable in vivo. Our DoD project involves developing computational models of the hippocampal and entorhinal cortex circuitry used in spatial navigation, higher level decision making circuits, and integrating the models with agents learning to solve navigation tasks using neurobiologically-inspired learning rules. This project includes mathematicians and robotics researchers at UTK and CMU.

Recent breakthroughs in neurobiology indicate that time is ripe to understand the cellular-level mechanisms of conscious experience. Accordingly, we have recently proposed that conscious processing depends on the integration between top-down and bottom-up information streams and that there exists a specific cellular mechanism that gates this integration. I will first describe this cellular mechanism and demonstrate how it controls signal propagation within the thalamocortical system. Then I will show how this cellular-level mechanism provides a natural explanation for why conscious experience is modulated by top-down processing. Besides shining new light on the neural basis of consciousness, this perspective unravels the mechanisms of internally generated perception, such as dreams, imagery, and hallucinations.